Home  |  Top News  |  Most Popular  |  Video  |  Multimedia  |  News Feeds  |  Feedback
  Medicine  |  Nature & Earth  |  Biology  |  Technology & Engineering  |  Space & Planetary  |  Psychology  |  Physics & Chemistry  |  Economics  |  Archaeology
Top > Medicine, Health Care > Childhood Adversity Increases Risk for… >
Childhood Adversity Increases Risk for Depression And Chronic Inflammation

Published: July 3, 2012.
By Elsevier
http://www.elsevier.com

Philadelphia, PA, July 3, 2012 – When a person injures their knee, it becomes inflamed. When a person has a cold, their throat becomes inflamed. This type of inflammation is the body's natural and protective response to injury.

Interestingly, there is growing evidence that a similar process happens when a person experiences psychological trauma. Unfortunately, this type of inflammation can be destructive.

Previous studies have linked depression and inflammation, particularly in individuals who have experienced early childhood adversity, but overall, findings have been inconsistent. Researchers Gregory Miller and Steve Cole designed a longitudinal study in an effort to resolve these discrepancies, and their findings are now published in a study in Biological Psychiatry.

They recruited a large group of female adolescents who were healthy, but at high risk for experiencing depression. The volunteers were then followed for 2 ½ years, undergoing interviews and giving blood samples to measure their levels of C-reactive protein and interleukin-6, two types of inflammatory markers. Their exposure to childhood adversity was also assessed.

The researchers found that when individuals who suffered from early childhood adversity became depressed, their depression was accompanied by an inflammatory response. In addition, among subjects with previous adversity, high levels of interleukin-6 forecasted risk of depression six months later. In subjects without childhood adversity, there was no such coupling of depression and inflammation.

Dr. Miller commented on their findings: "What's important about this study is that it identifies a group of people who are prone to have depression and inflammation at the same time. That group of people experienced major stress in childhood, often related to poverty, having a parent with a severe illness, or lasting separation from family. As a result, these individuals may experience depressions that are especially difficult to treat."

Another important aspect to their findings is that the inflammatory response among the high-adversity individuals was still detectable six months later, even if their depression had abated, meaning that the inflammation is chronic rather than acute. "Because chronic inflammation is involved in other health problems, like diabetes and heart disease, it also means they have greater-than-average risk for these problems. They, along with their doctors, should keep an eye out for those problems," added Dr. Miller.

"This study provides important additional support for the notion that inflammation is an important and often under-appreciated factor that compromises resilience after major life stresses. It provides evidence that these inflammatory states persist for long periods of time and have important functional correlates," said Dr. John Krystal, Editor of Biological Psychiatry.

Further research is necessary, to extend the findings beyond female adolescents and particularly in individuals with more severe, long-term depression. However, findings such as these may eventually help doctors and clinicians better manage depression and medical illness for particularly vulnerable patients.




Show Reference »


Translate this page: Chinese French German Italian Japanese Korean Portuguese Russian Spanish


 
All comments are reviewed before being posted. We cannot accept messages that refer a product, or web site.If you are looking for a response to a question please use our another feedback page.
Related »

Depression 
3/1/12 
Depression Could Be Evolutionary Byproduct of Immune System
By Emory University
Depression is common enough – afflicting one in ten adults in the United States – that it seems the possibility of depression must be "hard-wired" into our brains. This …
Depression 
9/20/11 
Depression Associated with Increased Risk of Stroke And Stroke-related Death
By JAMA and Archives Journals
CHICAGO – An analysis of nearly 30 studies including more than 300,000 patients finds that depression is associated with a significantly increased risk of developing stroke and dying from …
Depression 
10/2/13 
Depression May Increase Your Risk of Parkinson's Disease
By American Academy of Neurology
MINNEAPOLIS -- People who are depressed may have triple the risk of developing Parkinson's disease, according to a study published in the October 2, 2013, online issue of Neurology¬ …
People 
10/24/11 
Daily Smoking, Low Mastery Associated with Repeat Episodes of Depression
By Canadian Medical Association Journal
Previous depression, daily smoking and a lack of control over life circumstances — or "low mastery" — are risk factors for repeat episodes of depression, states an article in …
Depression 
3/16/11 
Managing Post-stroke Depression Improves Physical Functioning
By Indiana University School of Medicine
INDIANAPOLIS – Stroke patients who are not successfully treated for depression are at higher risk of losing some of their capability to function normally, according to a study in …
Studies 
5/16/11 
★★★ 

Researchers Identify DNA Region Linked to Depression
By Washington University School of Medicine
Depression 
4/17/12 
First Blood Test to Diagnose Major Depression in Teens
By Northwestern University
A Northwestern Medicine scientist has developed the first blood test to diagnose major depression in teens, a breakthrough approach that allows an objective diagnosis by measuring a specific set …
Boys 
2/18/14 
★★★★ 
First Biological Marker for Major Depression Could Enable Better Diagnosis And Treatment
By Wellcome Trust
Teenage boys who show a combination of depressive symptoms and elevated levels of the 'stress hormone' cortisol are up to fourteen times more likely to develop major depression than …
Diabetes 
2/24/14 
Specialized Cognitive Therapy Improves Blood Sugar Control in Depressed Diabetes Patients
By Massachusetts General Hospital
Although maintaining good blood sugar control is crucial for avoiding complications of diabetes, it has been estimated that only about half of patients are successful in meeting target blood …
Depression 
8/15/14 
Depression Often Untreated in Parkinson's Disease
By Northwestern University
Depression is known to be a common symptom of Parkinson's disease, but remains untreated for many patients, according to a new study by Northwestern Medicine investigators in collaboration with …
Depression 
11/27/13 
Modafinil Reduces Depression's Severity When Taken with Antidepressants
By University of Cambridge
A new study has concluded that taking the drug modafinil, typically used to treat sleep disorders, in combination with antidepressants reduces the severity of depression more effectively than taking …
Depression 
3/26/13 
People with Depression May Not Reap Full Benefits of Healthy Behaviors
By Duke University Medical Center
DURHAM, N.C. -- Depression may inhibit the anti-inflammatory effects typically associated with physical activity and light-to-moderate alcohol consumption, according to researchers at Duke Medicine. …
Patients 
5/11/11 
Depression Associated with Poor Medication Adherence in Patients with Chronic Illnesses
By RAND Corporation
People who are depressed are less likely to adhere to medications for their chronic health problems than patients who are not depressed, putting them at increased risk of poor …
More » 
 
© Newsline Group  |  About  |  Privacy Policy  |  Feedback  |  Mobile  |  Japanese Edition
All contents are copyright of their owners except U.S. Government works. U.S. Government works are assumed to be in the public domain unless otherwise noted. Everything else copyright ScienceNewsline.