Home  |  Top News  |  Most Popular  |  Video  |  Multimedia  |  News Feeds  |  Feedback
  Medicine  |  Nature & Earth  |  Biology  |  Technology & Engineering  |  Space & Planetary  |  Psychology  |  Physics & Chemistry  |  Economics  |  Archaeology
Top > Medicine, Health Care > A Study Demonstrates That Ibuprofen… >

A Study Demonstrates That Ibuprofen Improves Bone Repair After Surgery Or a Fracture

Published: July 3, 2012.
Released by University of Granada  

A study conducted at the University of Granada hasdemonstrated that ibuprofen ­–a non-steroidal anti-inflammatory drug (NSAID)­– has beneficial effects on bone repair after afracture or following bone surgery.

In vitro tests demonstrated that –unlike other NSAIDs– when a therapeutic dose of ibuprofen is administered, it has no negative effects on the proliferation and synthesis of obsteoblast osteocalcin, a cell which is directly involved in the formation and regeneration of bones.

Osteoblast cells are bone cells that synthesize the bone matrix. Consequently, osteoblasts play a major role in bone development, growth, maintenance and repair.

Positive Results

In an article recently published in the prestigious Journal of Bone and Mineral Metabolism, the University of Granada researchers report the positive effects of ibuprofen on bone repair. The researchers are members of the research group BIO277, which studies the effects of different pharmacological and non-pharmacological therapies on obsteoblast cells.

The primary author of this article, Concepción Ruiz Rodríguez, a professor at the University of Granada Nursing Department states that "up to date, we had little information on the effects of ibuprofen on osteoblast cells". The University of Granada study demonstrates that a therapeutic dose of ibuprofen (5-25µm.) does not inhibit the proliferation and synthesis of osteocalcinin the MG-63 cell line. However, when higher doses are administered (>25 µm.) they may activate other cells, which might explain theexpression of membrane markers and the decrease in the phagocytic capacity.






The above story is based on materials provided by University of Granada.

Translate this page: Chinese French German Italian Japanese Korean Portuguese Russian Spanish


comments powered by Disqus


Related »

Channels 
9/26/11 
Scientists Model the Pathways of Pain-blocking Meds
Benzocaine, a commonly used local anesthetic, may more easily wiggle into a cell's membrane when the membrane is made …
Show 
10/6/14 
Researchers Redefine Hypothesis on Holes in the Brain
Over the years, researchers have described how some of the body's cells have giant channels – a kind of …
Channels 
12/22/11 
Study Uncovers Clues to What Makes Anesthetics Work
Physicians use inhalation anesthetics in a way that is incredibly safe for patients, but very little is known about …
Membrane 
4/5/13 
MDC And FMP Researchers Identify Edema Inhibitor
Researchers of the Max Delbrück Center for Molecular Medicine (MDC) and the Leibniz Institute of Molecular Pharmacology (FMP) in …
More » 
 
© Newsline Group  |  About  |  Privacy Policy  |  Feedback  |  Mobile