Home  |  Top News  |  Most Popular  |  Video  |  Multimedia  |  News Feeds  |  Feedback
  Medicine  |  Nature & Earth  |  Biology  |  Technology & Engineering  |  Space & Planetary  |  Psychology  |  Physics & Chemistry  |  Economics  |  Archaeology
Top > Biology > 'Selfish' DNA in Animal Mitochondria… >
'Selfish' DNA in Animal Mitochondria Offers Possible Tool to Study Aging

Published: August 10, 2012.
By Oregon State University
http://oregonstate.edu

CORVALLIS, Ore. – Researchers at Oregon State University have discovered, for the first time in any animal species, a type of "selfish" mitochondrial DNA that is actually hurting the organism and lessening its chance to survive – and bears a strong similarity to some damage done to human cells as they age.

The findings, just published in the journal PLoS One, are a biological oddity previously unknown in animals. But they may also provide an important new tool to study human aging, scientists said.

Such selfish mitochondrial DNA has been found before in plants, but not animals. In this case, the discovery was made almost by accident during some genetic research being done on a nematode, Caenorhabditis briggsae – a type of small roundworm.

"We weren't even looking for this when we found it, at first we thought it must be a laboratory error," said Dee Denver, an OSU associate professor of zoology. "Selfish DNA is not supposed to be found in animals. But it could turn out to be fairly important as a new genetic model to study the type of mitochondrial decay that is associated with human aging."

DNA is the material that holds the basic genetic code for living organisms, and through complex biological processes guides beneficial cellular functions. Some of it is also found in the mitochondria, or energy-producing "powerhouse" of cells, which at one point in evolution was separate from the other DNA.

The mitochondria generally act for the benefit of the cell, even though it is somewhat separate. But the "selfish" DNA found in some plant mitochondria – and now in animals – has major differences. It tends to copy itself faster than other DNA, has no function useful to the cell, and in some cases actually harms the cell. In plants, for instance, it can affect flowering and sometimes cause sterility.

"We had seen this DNA before in this nematode and knew it was harmful, but didn't realize it was selfish," said Katie Clark, an OSU postdoctoral fellow. "Worms with it had less offspring than those without, they had less muscle activity. It might suggest that natural selection doesn't work very well in this species."

That's part of the general quandary of selfish DNA in general, the scientists said. If it doesn't help the organism survive and reproduce, why hasn't it disappeared as a result of evolutionary pressure? Its persistence, they say, is an example of how natural selection doesn't always work, either at the organism or cellular level. Biological progress is not perfect.

In this case, the population sizes of the nematode may be too small to eliminate the selfish DNA, researchers said.

What's also interesting, they say, is that the defects this selfish DNA cause in this roundworm are surprisingly similar to the decayed mitochondrial DNA that accumulates as one aspect of human aging. More of the selfish DNA is also found in the worms as they age.

Further study of these biological differences may help shed light on what can cause the mitochondrial dysfunction, Denver said, and give researchers a new tool with which to study the aging process.




Translate this page: Chinese French German Italian Japanese Korean Portuguese Russian Spanish


 
All comments are reviewed before being posted. We cannot accept messages that refer a product, or web site.If you are looking for a response to a question please use our another feedback page.
Related »

Modern 
1/28/14 
★★★ 
New Method Rescues DNA from Contaminated Neandertal Bones
By Uppsala University
Retrieval of ancient DNA molecules is usually performed with special precautions to prevent DNA from researchers or the environment to get mixed in with the DNA from the fossil. …
Unique 
3/25/13 
Smithsonian Scientists Use DNA to Quickly Unravel Relationship Between Plants And Insects
By Smithsonian
Studying the relationship between plants and the insects that feed on them is an arduous task, as it must be done through direct observation. It can take years for …
Mitochondrial 
10/3/13 
New Advances in the Study of Human Mitochondrial DNA
By Universitat Autonoma de Barcelona
A study concerning the evolution of mitochondrial DNA, performed by researchers from the Universitat Autònoma de Barcelona (UAB), has allowed to determine the frequency and pattern of heteroplasmy in …
Sequence 
7/28/13 
★★ 
Breakthrough in Detecting DNA Mutations Could Help Treat Tuberculosis, Cancer
By University of Washington
The slightest variation in a sequence of DNA can have profound effects. Modern genomics has shown that just one mutation can be the difference between successfully treating a disease …
Sima 
12/4/13 
Oldest Hominin DNA Sequenced
By Max-Planck-Gesellschaft
Using novel techniques to extract and study ancient DNA researchers at the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, have determined an almost complete mitochondrial genome sequence …
Slide 
10/6/11 
Vectors of Bluetongue Get a Name
By Institute of Tropical Medicine Antwerp
Scientists of the Antwerp Institute of Tropical Medicine (ITG) have developed a molecular technique to easily and dependably identify the biting midges that spread bluetongue disease. Until know this …
Palm 
12/30/13 

Tell Me Your Barcode, And I Will Tell You What Palm You Are
By Pensoft Publishers
More » 
 
© Newsline Group  |  About  |  Privacy Policy  |  Feedback  |  Mobile  |  Japanese Edition