Japanese  
  Home  |  Top News  |  Most Popular  |  Video  |  Multimedia  |  News Feeds  |  Feedback
  Medicine  |  Nature & Earth  |  Biology  |  Technology & Engineering  |  Space & Planetary  |  Psychology  |  Physics & Chemistry  |  Economics  |  Archaeology
Top > Technology & Engineering > Body Heat, Fermentation Drive New… >
Body Heat, Fermentation Drive New Drug-delivery 'Micropump'

Published: September 11, 2012.
By Purdue University
http://www.purdue.edu/

WEST LAFAYETTE, Ind. – Researchers have created a new type of miniature pump activated by body heat that could be used in drug-delivery patches powered by fermentation.

The micropump contains bakers yeast and sugar in a small chamber. When water is added and the patch is placed on the skin, the body heat and the added water causes the yeast and sugar to ferment, generating a small amount of carbon dioxide gas. The gas pushes against a membrane and has been shown to continually pump for several hours, said Babak Ziaie, a Purdue University professor of electrical and computer engineering and biomedical engineering.

Such miniature pumps could make possible drug-delivery patches that use arrays of "microneedles" to deliver a wider range of medications than now possible with conventional patches. Unlike many other micropumps under development or in commercial use, the new technology requires no batteries, said Ziaie, who is working with doctoral student Manuel Ochoa.

"This just needs yeast, sugar, water and your own body heat," Ziaie said.

The robustness of yeast allows for long shelf life, and the design is ideal for mass production, Ochoa said.

"It would be easy to fabricate because it's just a few layers of polymers sandwiched together and bonded," he said.

Findings were detailed in a research paper published online in August in the journal Lab on a Chip. The paper was written by Ochoa and Ziaie, and the research is based at Purdue's Birck Nanotechnology Center in the university's Discovery Park.

The "the microorganism-powered thermopneumatic pump" is made out of layers of a rubberlike polymer, called polydimethylsiloxane, which is used commercially for diaphragms in pumps. The prototype is 1.5 centimeters long.

Current "transdermal" patches are limited to delivering drugs that, like nicotine, are made of small hydrophobic molecules that can be absorbed through the skin, Ziaie said.

"Many drugs, including those for treating cancer and autoimmune disorders cannot be delivered with patches because they are large molecules that won't go through the skin," he said. "Although transdermal drug delivery via microneedle arrays has long been identified as a viable and promising method for delivering large hydrophilic molecules across the skin, a suitable pump has been hard to develop."

Patches that used arrays of tiny microneedles could deliver a multitude of drugs, and the needles do not cause pain because they barely penetrate the skin, Ziaie said. The patches require a pump to push the drugs through the narrow needles, which have a diameter of about 20 microns, or roughly one-fourth as wide as a human hair.

Most pumps proposed for drug-delivery applications rely on an on-board power source, which is bulky, costly and requires complex power-management circuits to conserve battery life. "Our approach is much more simple," Ziaie said. "It could be a disposable transdermal pump. You just inject water into the patch and place it on your skin. After it's used up, you would through it away."

Researchers have filed an application for a provisional patent on the device.


Show Reference »


Translate this page: Chinese French German Italian Japanese Korean Portuguese Russian Spanish


 
All comments are reviewed before being posted. We cannot accept messages that refer a product, or web site.If you are looking for a response to a question please use our another feedback page.
Related »

Ziaie 
11/20/12 

Scotch Tape Finds New Use as Grasping 'Smart Material'
By Purdue University
Kamrin 
4/5/12 
Shifting Sands: New Model Predicts How Sand And Other Granular Materials Flow
By Massachusetts Institute of Technology
Sand in an hourglass might seem simple and straightforward, but such granular materials are actually tricky to model. From far away, flowing sand resembles a liquid, streaming down the …
Water 
6/16/14 
★ 
Researchers 'Cage' Water to See It Change Form
By University of Southampton
Scientists are using a pioneering method of 'caging' and cooling water molecules to study the change in orientation of the magnetic nuclei at the centre of each hydrogen atom …
Muscles 
3/23/12 
★ 
Researchers Unveil Robot Jellyfish Built on Nanotechnology
By University of Texas at Dallas
Researchers at The University of Texas at Dallas and Virginia Tech have created an undersea vehicle inspired by the common jellyfish that runs on renewable energy and could be …
Membrane 
7/23/14 

ETH Student Develops Filter for Clean Water Around the World
By ETH Zurich
Wave 
5/13/14 
The Physics of Ocean Undertow
By American Institute of Physics
WASHINGTON D.C. May 13, 2014 -- People standing on a beach often feel the water tugging the sand away from under their feet. This is the undertow, the current …
Metal 
8/17/11 

Airbus Cockpits Made Using Fusion Reactor Technology
By European Fusion Development Agreement (EFDA)
More » 
 
ScienceNewsline  |  About  |  Privacy Policy  |  Feedback  |  Mobile  |  Japanese Edition
The selection and placement of stories are determined automatically by a computer program. All contents are copyright of their owners except U.S. Government works. U.S. Government works are assumed to be in the public domain unless otherwise noted. Everything else copyright ScienceNewsline.