Home  |  Top News  |  Most Popular  |  Video  |  Multimedia  |  News Feeds  |  Feedback
  Medicine  |  Nature & Earth  |  Biology  |  Technology & Engineering  |  Space & Planetary  |  Psychology  |  Physics & Chemistry  |  Economics  |  Archaeology
Top > Medicine, Health Care > Purple Corn Compound May Aid… >
Purple Corn Compound May Aid in Developing Future Treatments for Type 2 Diabetes, Kidney Disease

Published: September 19, 2012.
By American Physiological Society
http://www.the-aps.org

BETHESDA, Md. (Sept. 18, 2012)—Diabetic nephropathy is one of the most serious complications related to diabetes, often leading to end-stage kidney disease. Purple corn grown in Peru and Chile is a relative of blue corn, which is readily available in the U.S. The maize is rich in anthocyanins (also known as flavonoids), which are reported to have anti-diabetic properties. Scientists from the Department of Food and Nutrition and Department of Biochemistry at Hallym University in Korea investigated the cellular and molecular activity of purple corn anthocyanins (PCA) to determine whether and how it affects the development of diabetic nephropathy (DN). Their findings suggest that PCA inhibits multiple pathways involved in the development of DN, which may help in developing therapies aimed at type 2 diabetes and kidney disease.

The study is entitled "Purple corn anthocyanins inhibit diabetes-associated glomerular monocyte activation and macrophage infiltration" http://bit.ly/SlrkRY. It appears in the online edition of the American Journal of Physiology – Renal Physiology, published by the American Physiological Society (APS; www.the-aps.org).

Methodology

Researcher Min-Kyung Kang and colleagues performed a two-part study, an in vitro experiment investigating the effects of PCA on human endothelial cells cultured under hyperglycemic kidney conditions and an in vivo study that investigated the effects of PCA on kidney tissue in diabetic mice. In the in vitro experiment, cultured cells were exposed to 1-20 µg/ml of PCA for six hours (control cells were not exposed), then assessed for level of monocyte-endothelial cell adhesion, a major factor in the development of diabetic glomerulosclerosis. In the in vivo experiment, diabetic and control mice were dosed with PCA for eight weeks, then changes in kidney tissue were assessed and immunohistological analyses were performed. Kidney tissue was further analyzed for levels of inflammatory chemokines, which are key components in DN.

Results

Researchers found that in human endothelial cells cultured in hyperglycemic kidney conditions, induction of endothelial cell adhesion molecules decreased in a dose-dependent manner with PCA exposure, meaning that the PCA likely interfered with cell-cell adhesion in glomeruli. PCA also appeared to interfere with leukocyte recruitment and adhesion to glomerular endothelial cells. In diabetic mice, PCA exposure slowed mesangial expansion and interrupted the cellular signaling pathway that may instigate glomerular adhesion and infiltration of inflammatory cells responsible for diabetic glomerulosclerosis. Finally, PCA inhibited levels of macrophage inflammatory protein-2 and monocyte chemotactic protein-1 in kidney tissue, demonstrating that it may inhibit macrophage infiltration, which is closely related to renal inflammation.

Importance of the Findings

The research suggests that anthocyanins may be the main biofunctional compound in purple corn and could protect against mesangial activation of monocytes and infiltration of macrophages in glomeruli—the two major contributors to DN. The research further suggests that renoprotection by PCA against mesangial activation may be specific therapies targeting diabetes-associated diabetic glomerulosclerosis and renal inflammation. Finally, PCA supplementation may be an important strategy in preventing renal vascular disease in type 2 diabetes.

"PCA may be a potential renoprotective agent treating diabetes-associated glomerulosclerosis," wrote the researchers.


Show Reference »


Translate this page: Chinese French German Italian Japanese Korean Portuguese Russian Spanish


 
All comments are reviewed before being posted. We cannot accept messages that refer a product, or web site.If you are looking for a response to a question please use our another feedback page.
Related »

Work 
12/6/11 
Poorly Contracting Uterus in Diabetic Women Increases Risk of Caesarean Birth
By University of Liverpool
Researchers at the University of Liverpool have found that the strength of uterine contractions in diabetic pregnant women is significantly weaker than in non-diabetic women, increasing the risk of …
Diabetic 
5/16/12 
Protective Molecule, ACE2, Also Proving Its Worth in Diabetic Patients
By University of Alberta Faculty of Medicine & Dentistry
ACE2, a molecule that has been shown to prevent damage in the heart, is now proving to be protective of the major organs that are often damaged in diabetic …
Nerve 
8/21/14 
Amplitude of Sensory Nerve Action Potential in Early Stage Diabetic Peripheral Neuropathy
By Neural Regeneration Research
Early diagnosis of diabetic peripheral neuropathy is important for the successful treatment of diabetes mellitus. Research group at the Fourth Affiliated Hospital of Kunming Medical University, China, led by …
Dpn 
2/22/12 
Prediabetes May Not Explain Diabetic Polyneuropathies
By Mayo Clinic
In a reversal of two decades of medical reports, a Mayo Clinic study finds the frequency of nerve damage called diabetic polyneuropathy is similar in prediabetic patients and healthy …
Mothers 
5/30/14 
Mothers of Women with PCOS Have Increased Risk of Early Death
By European Society of Human Reproduction and Embryology
Mothers of daughters with polycystic ovary syndrome (PCOS) have a significantly increased risk of death, particularly if they also have diabetes, when compared to the general population, according to …
Gurtner 
10/27/14 
New Drug Delivered Through a Skin Patch Shows Promise in Healing Diabetic Foot Ulcers
By American College of Surgeons
SAN FRANCISCO: A foot ulcer is typically a painful inconvenience to most people, but to a person with diabetes it could mean an infection, or worse, an amputation. But …
Human 
6/23/14 
Gut Microbe Levels Are Linked to Type 2 Diabetes And Obesity
By The Endocrine Society
CHICAGO, IL — People with Type 2 diabetes or obesity have changes in the composition of their intestinal micro-organisms—called the gut microbiota—that healthy people do not have, researchers from …
Case 
9/11/14 

Mice And Men Share a Diabetes Gene
By Ecole Polytechnique Fédérale de Lausanne
More » 
 
© Newsline Group  |  About  |  Privacy Policy  |  Feedback  |  Mobile  |  Japanese Edition