Home  |  Top News  |  Most Popular  |  Video  |  Multimedia  |  News Feeds  |  Feedback
  Medicine  |  Nature & Earth  |  Biology  |  Technology & Engineering  |  Space & Planetary  |  Psychology  |  Physics & Chemistry  |  Economics  |  Archaeology
Top > Medicine, Health Care > Liver Cells, Insulin-producing Cells, Thymus… >
Liver Cells, Insulin-producing Cells, Thymus Can Be Grown in Lymph Nodes, Pitt Team Finds

Published: September 27, 2012.
By University of Pittsburgh Schools of the Health Sciences
http://www.upmc.com/Pages/default.aspx

PITTSBURGH, Sept. 27, 2012 – Lymph nodes can provide a suitable home for a variety of cells and tissues from other organs, suggesting that a cell-based alternative to whole organ transplantation might one day be feasible, according to researchers at the University of Pittsburgh School of Medicine and its McGowan Institute for Regenerative Medicine. In a report recently published online in Nature Biotechnology, the research team showed for the first time that liver cells, thymus tissue and insulin-producing pancreatic islet cells, in an animal model, can thrive in lymph nodes despite being displaced from their natural sites.

Hepatitis virus infection, alcoholic cirrhosis and other diseases can cause so much damage that liver transplantation is the only way to save the patient, noted senior investigator Eric Lagasse, Pharm. D., Ph.D., associate professor, Department of Pathology, Pitt School of Medicine. Children with DiGeorge syndrome lack functional thymus glands to produce essential immune cells, and diabetes can be cured with a pancreas transplant.

"However, the scarcity of donor organs means many people will not survive the wait for transplantation," said Dr. Lagasse, whose lab is at the McGowan Institute. "Cell therapies are being explored, but introducing cells into tissue already ravaged by disease decreases the likelihood of successful engraftment and restoration of function."

In the study, his team tested the possibility of using lymph nodes, which are abundant throughout the body and have a rich blood supply, as a new home for cells from other organs in what is called an "ectopic" transplant.

They injected healthy liver cells from a genetically-identical donor animal into lymph nodes of mice at various locations. The result was an enlarged, liver-like node that functioned akin to the liver; in fact, a single hepatized lymph node rescued mice that were in danger of dying from a lethal metabolic liver disease. Likewise, thymus tissue transplanted into the lymph node of mice that lacked the organ generated functional immune systems, and pancreatic islet cell transplants restored normal blood sugar control in diabetic animals.

"Our goal is not necessarily to replace the entire liver, for example, but to provide sufficient cell mass to stabilize liver function and sustain the patient's life," Dr. Lagasse said. "That could buy time until a donor organ can be transplanted. Perhaps, in some cases, ectopic cell transplantation in the lymph node might allow the diseased organ to recover."


Show Reference »


Translate this page: Chinese French German Italian Japanese Korean Portuguese Russian Spanish


 
All comments are reviewed before being posted. We cannot accept messages that refer a product, or web site.If you are looking for a response to a question please use our another feedback page.
Related »

Cells 
2/22/12 
IDIBELL Researchers Take a Step Forward in Transplanting Pig Cells to Regenerate Human Cartilage
By IDIBELL-Bellvitge Biomedical Research Institute
Researchers from the Bellvitge Biomedical Research Institute (IDIBELL) have studied for the first time the response of human NK cells (Natural Killer) against porcine chondrocytes (cartilage cells). The …
Transplant 
9/15/10 
King's College London Reveals Promising Techniques for Extending the Life of an Organ Transplant
By King's College London
Experts from the Medical Research Council (MRC) Centre for Transplantation at King's College London, based at Guy's Hospital, have revealed exciting new scientific developments for people with an organ …
System 
11/25/13 
Researchers Describe 1 Mechanism That Favors Rejection in Transplantation of Porcine Cartilage in Humans
By IDIBELL-Bellvitge Biomedical Research Institute
Researchers at the Bellvitge Institute of Biomedical Research (IDIBELL) led by Cristina Costa from the New Therapies on Genes and Transplantation group have shown that inhibition of one of …
Cells 
5/16/13 

Stem-cell-based Strategy Boosts Immune System in Mice
By University of California - San Francisco
Mhc 
8/30/11 
Vaccine Linked to 'Bleeding Calf Syndrome'
By BioMed Central
Bleeding calf syndrome (bovine neonatal pancytopenia or BNP) affects new born calves resulting in low blood cell counts and depletion of the bone marrow. It first emerged in 2007 …
Hla 
8/3/12 
Unexpected Variation in Immune Genes Poses Difficulties for Transplantation
By Cell Press
Human HLA genes – the genes that allow our immune system to tell the difference between our own cells and foreign invaders – are evolving much more rapidly than …
Cells 
5/31/12 
'Simple And Effective' Injection Could Offer Hope for Treatment of Autoimmune Disease
By University of New South Wales
Australian researchers have uncovered a potential new way to regulate the body's natural immune response, offering hope of a simple and effective new treatment for auto-immune diseases. Auto-immune …
Umscs 
4/12/11 
Umbilical Cord Blood-derived Stem Cells Studied for Lupus Therapy
By Cell Transplantation Center of Excellence for Aging and Brain Repair
Tampa, Fla. (April 11, 2011) – Human umbilical cord blood-derived mensenchymal stem cells (uMSCs) have been found to offer benefits for treating lupus nephritis (LN) when transplanted into mouse …
Inflammation 
7/29/12 
Cell Receptor Has Proclivity for T Helper 9 Cells, Airway Inflammation
By Brigham and Women's Hospital
BOSTON, MA—A research team led by Xian Chang Li, MD, PhD, Brigham and Women's Hospital (BWH) Transplantation Research Center, has shed light on how a population of lymphocytes, called …
More » 
 
© Newsline Group  |  About  |  Privacy Policy  |  Feedback  |  Mobile  |  Japanese Edition