Home  |  Top News  |  Most Popular  |  Video  |  Multimedia  |  News Feeds  |  Feedback
  Medicine  |  Nature & Earth  |  Biology  |  Technology & Engineering  |  Space & Planetary  |  Psychology  |  Physics & Chemistry  |  Economics  |  Archaeology
Top > Medicine, Health Care > Novel MRI Technique Could Reduce… >
Novel MRI Technique Could Reduce Breast Biopsies

Published: October 2, 2012.
By Radiological Society of North America
http://www.rsna.org

OAK BROOK, Ill. – Water diffusion measurements with MRI could decrease false-positive breast cancer results and reduce preventable biopsies, according to a new study published online in the journal Radiology. Researchers said the technique also could improve patient management by differentiating high-risk lesions requiring additional workup from other non-malignant subtypes.

Dynamic contrast-enhanced MRI (DCE-MRI) has emerged in recent years as a useful tool in breast cancer detection and staging. One of its primary limitations is a substantial number of false-positive findings that require biopsies.

"Many benign lesions demonstrate enhancement on DCE-MRI," said Savannah C. Partridge, Ph.D., research associate professor at the University of Washington, Seattle Cancer Care Alliance. "We need another means for differentiating benign lesions from malignancies."

One possible solution is diffusion-weighted imaging (DWI), an MRI technique that calculates the apparent diffusion coefficient (ADC)—a measure of how water moves through tissue.

"DWI has been used mostly in neurological applications, but it's been studied more recently in breast imaging," Dr. Partridge said. "It only adds a couple of minutes to the MRI exam and does not require additional contrast or any extra hardware."

Research has shown that DWI is a promising tool for distinguishing between benign and malignant breast lesions. Normal breast tissue has a high ADC because water moves through it relatively freely, while most cancers have a lower ADC because their cells are more tightly packed and restrict water motion. However, significant overlap exists between the ADC values of non-malignant lesions and breast malignancies, and little is known about the ADC values of specific subtypes of non-malignant lesions.

For the new study, Dr. Partridge and colleagues evaluated the DWI characteristics of non-malignant lesions in 165 women. Based on ADC values above a previously determined diagnostic threshold, DWI successfully characterized 46 percent of non-malignant breast lesions identified as false-positive findings on DCE-MRI as benign.

"We were excited to see the number of false positives that could be reduced through this approach," Dr. Partridge said. "DWI gives us extra microstructural information to distinguish among lesions. We can use ADC values to draw a cutoff above which we might not need to do a biopsy."

The research team is planning a multicenter trial to validate the findings and determine how to best to incorporate ADC measures into clinical breast MRI interpretations.

"We are very motivated to translate this promising technology to a clinically useful breast imaging tool," Dr. Partridge said.


Show Reference »


Translate this page: Chinese French German Italian Japanese Korean Portuguese Russian Spanish


Disclaimer: The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the ScienceNewsline.
Related »

Screening 
8/20/13 
Multicenter Trial Finds BI-RADS 3 Breast Lesions Have Low Cancer Rate
By Radiological Society of North America
OAK BROOK, Ill. – Based on data from a multi-site imaging trial involving more than 2,600 women, researchers say breast lesions categorized as 'probably benign' on supplemental screening ultrasound …
Zhu 
6/22/10 
Noninvasive Combination Technique May Reduce Number of Breast Biopsies
By Radiological Society of North America
OAK BROOK, Ill. – By combining two relatively inexpensive technologies based on sound and light waves, researchers hope to lower the rate at which women undergo breast biopsies for …
Optical 
11/9/10 
Combined Imaging Technologies May Better Identify Cancerous Breast Lesions
By Radiological Society of North America
OAK BROOK, Ill. – By combining optical and x-ray imaging, radiologists may be better able to distinguish cancer from benign lesions in the breast, according to a new study …
Indeterminate 
5/3/10 
Indeterminate Breast Lesions Found in High-risk Patients Should Be Evaluated Aggressively to Exclude Malignancy
By American College of Radiology / American Roentgen Ray Society
Short-term follow-up is often used to evaluate indeterminate breast lesions found on breast magnetic resonance imaging (MRI). However, researchers have found that indeterminate lesions (found in women with a …
Satake 
1/12/11 
Elastography Helps Identify Patients Who Need Biopsy
By American College of Radiology / American Roentgen Ray Society
A new ultrasound technique is proving valuable in distinguishing malignant from benign breast lesions in some patients – results that could mean fewer unnecessary breast biopsies, a new study …
 
3/28/14 

Aspartic Acid in the Hippocampus: A Biomarker for Postoperative Cognitive Dysfunction
By Neural Regeneration Research
 
3/19/14 
Postoperative Cognitive Dysfunction
By Deutsches Aerzteblatt International
Older persons, in particular, tend to suffer from memory lapses and other types of cognitive impairment after undergoing surgical procedures (postoperative cognitive dysfunction, POCD). Surgery has been performed on …
 
1/27/14 
NIH Grantees Develop Way to Make Old Antibiotic Work Against TB
By National Institute of Allergy and Infectious Diseases
Scientists supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have developed a method to synthesize modified forms of an …
More » 

Most Popular - Medicine »
GENES »
Loss of Memory in Alzheimer's Mice Models Reversed Through Gene Therapy
TUMORS »
The Immune System's Redesigned Role in Fighting Cancerous Tumors
LOS ANGELES (March 11, 2014) – Researchers in the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute eradicated solid tumors in laboratory mice using a novel combination of two targeted agents. …
MUTATIONS »
Applying Math to Biology: Software Identifies Disease-causing Mutations in Undiagnosed Illnesses
(SALT LAKE CITY)–A computational tool developed at the University of Utah (U of U) has successfully identified diseases with unknown gene mutations in three separate cases, U of U …
IRON »
Study: Iron Consumption Can Increase Risk for Heart Disease
WHOOPING »
Impact of Whooping Cough Vaccination Revealed
The most comprehensive study to date of the family of bacteria that causes whooping cough points to more effective vaccine strategies and reveals surprising findings about the bacteria's origin …
ScienceNewsline  |  About  |  Privacy Policy  |  Feedback  |  Mobile  |  Japanese
The selection and placement of stories are determined automatically by a computer program. All contents are copyright of their owners except U.S. Government works. U.S. Government works are assumed to be in the public domain unless otherwise noted. Everything else copyright ScienceNewsline.