Home  |  Top News  |  Most Popular  |  Video  |  Multimedia  |  News Feeds  |  Feedback
  Medicine  |  Nature & Earth  |  Biology  |  Technology & Engineering  |  Space & Planetary  |  Psychology  |  Physics & Chemistry  |  Economics  |  Archaeology
Top > Medicine, Health Care > Novel MRI Technique Could Reduce… >
Novel MRI Technique Could Reduce Breast Biopsies

Published: October 2, 2012.
By Radiological Society of North America
http://www.rsna.org

OAK BROOK, Ill. – Water diffusion measurements with MRI could decrease false-positive breast cancer results and reduce preventable biopsies, according to a new study published online in the journal Radiology. Researchers said the technique also could improve patient management by differentiating high-risk lesions requiring additional workup from other non-malignant subtypes.

Dynamic contrast-enhanced MRI (DCE-MRI) has emerged in recent years as a useful tool in breast cancer detection and staging. One of its primary limitations is a substantial number of false-positive findings that require biopsies.

"Many benign lesions demonstrate enhancement on DCE-MRI," said Savannah C. Partridge, Ph.D., research associate professor at the University of Washington, Seattle Cancer Care Alliance. "We need another means for differentiating benign lesions from malignancies."

One possible solution is diffusion-weighted imaging (DWI), an MRI technique that calculates the apparent diffusion coefficient (ADC)—a measure of how water moves through tissue.

"DWI has been used mostly in neurological applications, but it's been studied more recently in breast imaging," Dr. Partridge said. "It only adds a couple of minutes to the MRI exam and does not require additional contrast or any extra hardware."

Research has shown that DWI is a promising tool for distinguishing between benign and malignant breast lesions. Normal breast tissue has a high ADC because water moves through it relatively freely, while most cancers have a lower ADC because their cells are more tightly packed and restrict water motion. However, significant overlap exists between the ADC values of non-malignant lesions and breast malignancies, and little is known about the ADC values of specific subtypes of non-malignant lesions.

For the new study, Dr. Partridge and colleagues evaluated the DWI characteristics of non-malignant lesions in 165 women. Based on ADC values above a previously determined diagnostic threshold, DWI successfully characterized 46 percent of non-malignant breast lesions identified as false-positive findings on DCE-MRI as benign.

"We were excited to see the number of false positives that could be reduced through this approach," Dr. Partridge said. "DWI gives us extra microstructural information to distinguish among lesions. We can use ADC values to draw a cutoff above which we might not need to do a biopsy."

The research team is planning a multicenter trial to validate the findings and determine how to best to incorporate ADC measures into clinical breast MRI interpretations.

"We are very motivated to translate this promising technology to a clinically useful breast imaging tool," Dr. Partridge said.


Show Reference »


Translate this page: Chinese French German Italian Japanese Korean Portuguese Russian Spanish


 
All comments are reviewed before being posted. We cannot accept messages that refer a product, or web site.If you are looking for a response to a question please use our another feedback page.
Related »

Months 
5/3/12 
Study Finds 'Overmanagement' of Benign Breast Disease
By American Roentgen Ray Society
Contrary to current guidelines, women with benign breast biopsies do not need follow-up at six months; they may not need close surveillance at all, a new study shows. …
Pinker 
6/24/14 
Combo Tumor Imaging Can Distinguish Malignant & Benign Breast Tumors, Help Avoid Biopsies
By American Association for Cancer Research
PHILADELPHIA — Imaging breast tumors using four approaches together can better distinguish malignant breast tumors from those that are benign, compared with imaging using fewer approaches, and this may …
Lesions 
5/3/12 
Surgical Excision Unnecessary in Some Patients with Benign Papillomas
By American Roentgen Ray Society
Imaging surveillance is an acceptable alternative to surgical excision in patients with benign papilloma, diagnosed at breast core biopsy without cell abnormalities, a new study shows. …
Data 
11/5/13 
Machines Learn to Detect Breast Cancer
By Inderscience Publishers
Software that can recognize patterns in data is commonly used by scientists and economics. Now, researchers in the US have applied similar algorithms to help them more accurately diagnose …
Indeterminate 
5/3/10 
Indeterminate Breast Lesions Found in High-risk Patients Should Be Evaluated Aggressively to Exclude Malignancy
By American College of Radiology / American Roentgen Ray Society
Short-term follow-up is often used to evaluate indeterminate breast lesions found on breast magnetic resonance imaging (MRI). However, researchers have found that indeterminate lesions (found in women with a …
Mastanduno 
1/24/14 

Researchers Developing New Approach for Imaging Dense Breasts for Abnormalities
By The Geisel School of Medicine at Dartmouth
More » 
 
© Newsline Group  |  About  |  Privacy Policy  |  Feedback  |  Mobile  |  Japanese Edition