Home  |  Top News  |  Most Popular  |  Video  |  Multimedia  |  News Feeds  |  Feedback
  Medicine  |  Nature & Earth  |  Biology  |  Technology & Engineering  |  Space & Planetary  |  Psychology  |  Physics & Chemistry  |  Economics  |  Archaeology
Top > Medicine, Health Care > Cancer Drug Shows Promise in… >

Cancer Drug Shows Promise in Eradicating Latent HIV Infection

Published: November 29, 2012.
Released by Federation of American Societies for Experimental Biology  

Bethesda, MD—Breakthrough drugs have made it possible for people to live with HIV longer than ever before, but more work must be done to actually cure the disease. One of the challenges researchers face involves fully eradicating the virus when it is latent in the body. A new report appearing in the December 2012 issue of the Journal of Leukocyte Biology suggests that a cancer drug, called JQ1, may be useful in purging latent HIV infection by activating the virus in the presence of potent therapy – essentially a dead end for the virus.

"This drug may be useful as adjunctive therapy in efforts to purge latent HIV reservoirs to eradicate infection," said Monty A. Montano, Ph.D., principal investigator from the Section of Infectious Diseases at Boston University Medical Campus, in Boston, Mass. "This drug functions synergistically with other HIV purging agents."

To make this discovery, scientists used cell lines that contained latent HIV, as well as cells from patients who were on potent antiretroviral therapy with no detectable virus in their blood. Researchers then added JQ1 to latently infected cells, at physiologic concentrations, and observed potent reactivation of latent HIV. The researchers also observed potent suppression of inflammatory genes in genome-wide expression studies using the same cells. JQ1 reactivation of latent HIV may make it vulnerable to current therapies.

"One thing that's been made clear by the decades of HIV research is that there is no magic bullet for curing this disease," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "Rather, the progress that's been made has been a series of incremental steps that often build on other previously developed therapies. The hope is that the ability of JQ1 to make latent HIV 'visible' to other HIV drugs described in this report will be another cog in the gearwheel of an HIV cure."




The above story is based on materials provided by Federation of American Societies for Experimental Biology.

Translate this page: Chinese French German Italian Japanese Korean Portuguese Russian Spanish


comments powered by Disqus


Related »

Ucsf 
12/22/11 
Pathogenic Landscape of HIV: Hundreds of Connections Between Viral And Human Proteins Identified
In perhaps the most comprehensive survey of the inner workings of HIV, an international team of scientists led by …
Cocaine 
9/30/13 
Cocaine Use May Increase HIV Vulnerability
Bethesda, MD -- Cocaine use may increase one's vulnerability to HIV infection, according to a new research report published …
Cells 
2/2/15 
Break on Through to the Other Side: How HIV Penetrates the Blood-brain Barrier
Although it is known that HIV can enter the brain early during infection, causing inflammation and memory/cognitive problems, exactly …
Technology 
12/1/10 
A Powerful New Technology to Identify HIV Inhibitors
EASY-HIT** is a new cell-based assay system for simple and reliable testing of HIV inhibitors. This system was developed …
Receptor 
9/12/13 
Molecular Structure Reveals How HIV Infects Cells
SHANGHAI, CHINA, AND LA JOLLA, CA – In a long-awaited finding, a team of Chinese and US scientists has …
Hiv 
2/12/15 
An Aggressive Form of HIV Uncovered in Cuba
Engaging in unprotected sex with multiple partners increases the risk of contracting multiple strains of HIV, the virus that …
More » 
 
© Newsline Group  |  About  |  Privacy Policy  |  Feedback  |  Mobile