Home  |  Top News  |  Most Popular  |  Video  |  Multimedia  |  News Feeds  |  Feedback
  Medicine  |  Nature & Earth  |  Biology  |  Technology & Engineering  |  Space & Planetary  |  Psychology  |  Physics & Chemistry  |  Economics  |  Archaeology
Top > Medicine, Health Care > Vanderbilt Study Finds Diverse Genetic… >

Vanderbilt Study Finds Diverse Genetic Alterations in Triple-negative Breast Cancers

Published: December 7, 2012.
Released by Vanderbilt University Medical Center  

Most triple-negative breast cancer patients who were treated with chemotherapy to shrink the tumor prior to surgery still had multiple genetic mutations in their tumor cells, according to a study by Vanderbilt-Ingram Cancer Center (VICC) investigators.

Finding multiple mutations instead of just one primary mutation that can be targeted for therapy sheds more light on the challenges of treating triple-negative breast cancer.

The study, led by Justin Balko, Pharm.D., Ph.D., and research faculty in the laboratory of Carlos Arteaga, M.D., director of the Breast Cancer Program at VICC, was presented at the 2012 CTRC-AACR San Antonio Breast Cancer Symposium, held Dec. 4-8.

Approximately 15 percent of breast cancer patients in the U.S. have triple-negative cancer – a form of the disease that disproportionately affects young African-American women. Triple-negative breast cancer has traditionally been more difficult to treat than other forms of the disease.

"The standard of care for many patients with triple-negative breast cancer is to administer chemotherapy before surgery to shrink the tumor," Balko said. "Unfortunately, about 70 percent of patients still have some residual disease at the time of surgery, despite treatment."

Balko and colleagues profiled residual tumor tissue from 114 patients with triple-negative breast cancer who had received chemotherapy prior to surgery. Triple-negative breast cancer cells do not have estrogen receptors, progesterone receptors, or large amounts of the HER2/neu protein.

The investigators were able to evaluate DNA from 81 tumors and used deep sequencing to examine 182 oncogenes and tumor suppressors that are known to be altered in human cancers. Instead of finding similar genes affected among the patients, they found a diverse set of genes were altered.

"We already knew that triple-negative breast cancer is driven by a diverse group of genetic alterations," Balko said. "So, in one way, we fell further down this rabbit hole, but we also found some things that could be promising therapeutically, such as frequent MYC, MCL1 and JAK2 amplifications as well as mutations in the PI3K pathway."

The additional genetic alterations found in the study may provide targets for new therapies.

Balko said the next step is to confirm the findings in a larger patient group, and if the findings are replicated, broad molecular approaches will be needed to help develop personalized therapies for triple-negative breast cancer. It also will be necessary to explore the therapeutic sensitivity of breast cancers harboring these lesions in the laboratory to know how to treat patients who have these alterations.




The above story is based on materials provided by Vanderbilt University Medical Center.

Translate this page: Chinese French German Italian Japanese Korean Portuguese Russian Spanish


comments powered by Disqus


Related »

Breast 
2/28/13 
Groundbreaking UK Study Shows Key Enzyme Missing from Aggressive Form of Breast Cancer
LEXINGTON, Ky. (Feb. 28, 2013) – A groundbreaking new study led by the University of Kentucky Markey Cancer Center's Dr. Peter Zhou found that triple-negative breast cancer cells are …
Treatment 
3/19/12 
Breaking the Backbone of Triple-negative Breast Cancers
Putting the brakes on an abundant growth-promoting protein causes breast tumors to regress, according to a study published on March 19th in the Journal of Experimental Medicine. …
Triple-Negative 
11/12/12 
PI3-kinase And PARP Inhibitor Combo May Offer New Treatment Option for Triple-neg Breast Cancers
PHILADELPHIA — The simultaneous inhibition of two separate and seemingly unrelated pathways could potentially provide an effective treatment for women with triple-negative breast cancer, according to results of two …
Cancer 
3/14/12 
New Study Shows Promise for Developing New Treatments for Breast Cancer
A new study by University of Kentucky researchers provides insight into developing new treatment strategies for basal-like breast cancer, commonly known as triple-negative breast cancer. This cancer is associated …
Breast 
2/7/12 
PET Techniques Provide More Accurate Diagnosis, Prognosis in Challenging Breast Cancer Cases
In two new studies featured in the February issue of the Journal of Nuclear Medicine, researchers are revealing how molecular imaging can be used to solve mysteries about difficult …
Microrna 
2/7/13 
Triple-negative Breast Cancer Subtypes Identified Using MicroRNA
COLUMBUS, Ohio – A new, large-scale study of triple-negative breast cancer shows that small molecules called microRNA can be used to define four subtypes of this aggressive malignancy. …
Cells 
2/17/14 

New Finding Points to Potential Options for Attacking Stem Cells in Triple-negative Breast Cancer
More » 
 
© Newsline Group  |  About  |  Privacy Policy  |  Feedback  |  Mobile