Japanese  
  Home  |  Top News  |  Most Popular  |  Video  |  Multimedia  |  News Feeds  |  Feedback
  Medicine  |  Nature & Earth  |  Biology  |  Technology & Engineering  |  Space & Planetary  |  Psychology  |  Physics & Chemistry  |  Economics  |  Archaeology
Top > Medicine, Health Care > Low Adiponcetin Associated with Increased… >
Low Adiponcetin Associated with Increased Pancreatic Cancer Risk

Published: December 15, 2012.
By Journal of the National Cancer Institute
http://jncicancerspectrum.oupjournals.org

Low prediagnostic levels of circulating adiponectin were associated with an increased risk of pancreatic cancer, according to a study published December 14 in the Journal of the National Cancer Institute.

Pancreatic cancer is the fourth leading cause of cancer death in the U.S., but its etiology remains unclear. Adiponectin, a hormone secreted from fat cells, has insulin-sensitizing and anti-inflammatory properties. Low adiponectin plasma levels are associated with the insulin resistance that manifests in obesity and diabetes mellitus, both of which are risk factors for pancreatic cancer.

In order to determine if prediagnostic plasma levels of adiponectin were linked to an increased risk of pancreatic cancer, Ying Bao, M.D., Sc.D., Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, and colleagues, pooled the data from five prospective U.S. cohort studies, and matched 468 pancreatic cancer case subjects with 1,080 healthy control subjects by cohort, year of birth, smoking status, fasting status, and month of blood draw. They assessed the association between adiponectin and pancreatic cancer risk with conditional logistic regression.

The researchers found a statistically significant inverse association between prediagnostic plasma adiponectin levels and the risk of pancreatic cancer in the five prospective cohorts. "Our data provide additional evidence for a biological link between obesity, insulin resistance, and pancreatic cancer risk and also suggest an independent role of adiponectin in the development of pancreatic cancer," the authors write.

In an accompanying editorial, Jianliang Zhang, Ph.D., Associate Professor of Oncology and Steven N. Hochwald, M.D., Department of Surgical Oncology, both of the Roswell Park Cancer Institute, write that the study establishes a link between adiponectin levels and pancreatic cancer risk that suggests that metabolism contributes to the pathophysiology of pancreatic cancer. "Early detection by the assessment of adiponectin has the potential to improve the survival rates of pancreatic tumor patients," the authors write. "It is also inviting to speculate that therapeutic interventions to increase the levels of circulating adiponectin may prevent the development of pancreatic cancer and/or improve the survival of patients with malignancy."


Show Reference »


Translate this page: Chinese French German Italian Japanese Korean Portuguese Russian Spanish


 
This is form to send feedback to the editors. Tell us what you think about this article. All comments are not published. If you are looking for a response to a question please use our another feedback page.
Related »

Pancreatic 
7/25/11 
Study Examines Screening for Pancreatic Cancer in High-risk Populations
By American Society for Gastrointestinal Endoscopy
OAK BROOK, Ill. – July 25, 2011 – Researchers from New England report in a new study that using a tumor marker, serum CA 19-9, combined with an endoscopic …
Cancer 
10/1/12 

Smoking, Heavy Drinking Linked to Earlier Onset of Pancreatic Cancer
By University of Michigan Health System
Cancer 
4/28/11 
Researchers ID Promising Pancreatic Cancer Screening Marker
By University of Michigan Health System
ANN ARBOR, Mich. — Researchers at the University of Michigan Comprehensive Cancer Center have identified a protein that shows distinct changes in structure between pancreatic cancer, non-cancerous diseases and …
Pancreatic 
1/22/14 
Biomarkers in Blood Show Potential as Early Detection Method of Pancreatic Cancer
By The JAMA Network Journals
Researchers have identified diagnostic microRNA panels in whole blood that had the ability to distinguish, to some degree, patients with and without pancreatic cancer, according to a study in …
Cancer 
6/19/12 
Nerve Growth Factors Elevated in Pancreatic Cancer Model
By American Association for Cancer Research
LAKE TAHOE, Nev. — Severe pain is a major symptom of pancreatic cancer. The results of a new study show that four different factors involved in the growth and …
Screening 
4/22/13 
Diagnosis And Management of Pancreatic Cancer: A Review for Physicians
By Canadian Medical Association Journal
Pancreatic cancer is the fourth leading cause of death from cancer, and while family physicians in Canada only see 1 cases a year, the number of cases is expected …
More » 
 
ScienceNewsline  |  About  |  Privacy Policy  |  Feedback  |  Mobile  |  Japanese Edition
The selection and placement of stories are determined automatically by a computer program. All contents are copyright of their owners except U.S. Government works. U.S. Government works are assumed to be in the public domain unless otherwise noted. Everything else copyright ScienceNewsline.