Home  |  Top News  |  Most Popular  |  Video  |  Multimedia  |  News Feeds  |  Feedback
  Medicine  |  Nature & Earth  |  Biology  |  Technology & Engineering  |  Space & Planetary  |  Psychology  |  Physics & Chemistry  |  Economics  |  Archaeology
Top > Medicine, Health Care > Host Cholesterol Secretion Likely to… >
Host Cholesterol Secretion Likely to Influence Gut Microbiota

Published: December 19, 2012.
By American Society for Microbiology
http://www.asm.org

For more than half a century, researchers have known that the bacteria that colonize the gastrointestinal tract of mammals influence their host's cholesterol metabolism. Now, Jens Walter and colleagues of the University of Nebraska show that changes in cholesterol metabolism induced by diet can alter the gut flora. The research was published online ahead of print in the journal Applied and Environmental Microbiology.

In the study, the researchers added plant sterol esters to the diets of hamsters. The overall effect of this was to inhibit several bacterial taxa, from the families Coriobacteriacea and Erysipelotrichaceae, says Walter. But the immediate effect of the plant sterols was to physically block cholesterol absorption by the intestine. That decreased cholesterol levels in the liver and the plasma, prompting the hamster's body to respond by synthesizing more cholesterol. That, in turn, boosted cholesterol excretion into the gut, and that extra cholesterol was the direct inhibitor of those bacterial families.

"The abundance of these bacterial taxa and the levels of cholesterol in the fecal samples followed a mathematical model of bacterial inhibition," says Walter.

Practically speaking, the microbial inhabitants of the gut are part of the metabolic system. Researchers have shown that certain health problems are related to changes in the gut flora, such as can be induced by overuse of antibiotics. Since changes in diet can influence composition of the gut flora, health problems such as obesity might be targeted by dietary interventions designed to suppress bacteria that contribute to weight gain. "However, for these to be successful, we need to know which bacterial patterns not only are associated with disease, but actually contribute to it," says Walter, noting that his research showed that some alterations associated with metabolic disease might be the consequence, rather than the cause of the disorder.

Walter says that the work was a real student project. Among the coauthors, three were graduate students, and two were undergraduates. "As a supervisor, it is extremely nice to see young scientists work as a team, and staying dedicated through the five years that this project took to complete," he says.


Show Reference »


Translate this page: Chinese French German Italian Japanese Korean Portuguese Russian Spanish


 
All comments are reviewed before being posted. We cannot accept messages that refer a product, or web site.If you are looking for a response to a question please use our another feedback page.
Related »

Bacteria 
5/13/14 
TB Lung Infection Causes Changes in the Diversity of Gut Bacteria in Mice
By Johns Hopkins Medicine
Johns Hopkins researchers have found evidence in mice that a tuberculosis (TB) infection in the lungs triggers immune system signaling to the gut that temporarily decreases the diversity of …
System 
7/10/14 
In the Gut, Immunity Is a 2-way Street
By RIKEN
In recent years, it has become increasingly clear that many diseases are triggered or maintained by changes in bacterial communities in the gut. However, the general view up into …
Immune 
5/7/12 
Gut Flora Affects Maturation of B Cells in Infants
By University of Gothenburg
Infants whose gut is colonised by E. coli bacteria early in life have a higher number of memory B cells in their blood, reveals a study of infants carried …
Subjects 
12/7/13 
Decreased Diversity of Bacteria Microbiome in the Gut Is Associated with Risk of Colorectal Cancer
By Journal of the National Cancer Institute
Decreased diversity in the microbial community found in the human gut is associated with colorectal cancer, according to a new study published December 6 in the Journal of the …
Bacteria 
10/25/12 
★★★★ 
C'est Difficile
By Wellcome Trust Sanger Institute
In a new study out today, researchers used mice to identify a combination six naturally occurring bacteria that eradicate a highly contagious form of Clostridium difficile, an infectious bacterium …
Therapies 
9/2/11 
Study Linking Gut Microbe Type with Diet Has Implications for Fighting GI Disorders
By University of Pennsylvania School of Medicine
PHILADELPHIA – "You are what you eat" is familiar enough, but how deep do the implications go? An interdisciplinary group of investigators from the Perelman School of Medicine at …
Microbial 
7/11/14 
When Good Gut Bacteria Get Sick
By Brigham and Women's Hospital
Boston, MA – Being sick due to an infection can make us feel lousy. But what must the ecosystem of bacteria, or microbiota, colonizing our guts be going through …
More » 
 
© Newsline Group  |  About  |  Privacy Policy  |  Feedback  |  Mobile  |  Japanese Edition