Home  |  Top News  |  Most Popular  |  Video  |  Multimedia  |  News Feeds  |  Feedback
  Medicine  |  Nature & Earth  |  Biology  |  Technology & Engineering  |  Space & Planetary  |  Psychology  |  Physics & Chemistry  |  Economics  |  Archaeology
Top > Medicine, Health Care > Stroke Drug Kills Bacteria That… >

Stroke Drug Kills Bacteria That Cause Ulcers And Tuberculosis

Published: December 20, 2012.
Released by Federation of American Societies for Experimental Biology  

Bethesda, MD—A drug currently being used to treat ischemic strokes may prove to be a significant advance in the treatment of tuberculosis and ulcers. In a new research report appearing online in The FASEB Journal, a compound called ebselen effectively inhibits the thioredoxin reductase system in a wide variety of bacteria, including Helicobacter pylori which causes gastric ulcers and Mycobacterium tuberculosis which causes tuberculosis. Thioredoxin and thioredoxin reductase proteins are essential for bacteria to make new DNA, and protect them against oxidative stress caused by the immune system. Targeting this system with ebselen, and others compounds like it, represents a new approach toward eradicating these bacteria.

"This new antibacterial principle provides better chances of surviving an infection," said Arne Holmgren, M.D., Ph.D., a researcher involved in the work from the Division of Biochemistry in the Department of Medical Biochemistry and Biophysics, at Karolinska Institutet in Stockholm, Sweden. "Since ebselen is also an antioxidant, the present mechanism can be described as a 'two for the price of one' antioxidant action in inflammation, and specific targeting of multi-resistant bacterial complications and sepsis."

Building on previous observations where ebselen has shown antibacterial properties against some bacteria, Holmgren and colleagues hypothesized that the bacteria sensitive to ebselen relied solely on thioredoxin and thioredoxin reductase for essential cellular processes. They investigated this by testing it on strains of E. coli with deletions in the genes for thioredoxin, thioredoxin reductase and the glutaredoxin system. They found that strains with deletions in the genes coding for glutaredoxin system were much more sensitive than normal bacteria. Researchers further tested ebselen against Helicobacter pylori and Mycobacterium tuberculosis, which both naturally lack the glutaredoxin system and are frequently resistant to many commonly used antibiotics, and found both to be sensitive to ebselen.

"As rapidly as these organisms evolve, we need new drugs sooner rather than later," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "The fact that these scientists have found a new target for killing some of the most resistant bacteria is great news, but the fact that we already have at least one drug which we could possibly use now makes the news even better."




The above story is based on materials provided by Federation of American Societies for Experimental Biology.

Translate this page: Chinese French German Italian Japanese Korean Portuguese Russian Spanish


comments powered by Disqus


Related »

Clinical 
8/22/12 
NIH Uses Genome Sequencing to Help Quell Bacterial Outbreak in Clinical Center
For six months last year, a deadly outbreak of antibiotic-resistant bacteria kept infection-control specialists at the National Institutes of …
Sequencing 
2/23/11 
Researchers Use Genomics to Investigate TB Outbreak
Vancouver, BC - Scientists supported by Genome BC have set a new standard for studying outbreaks of infectious disease …
Female 
10/15/14 
★★★★ 
Researchers Look to Exploit Females' Natural Resistance to Infection
Researchers have linked increased resistance to bacterial pneumonia in female mice to an enzyme activated by the female sex …
Lungs 
9/28/12 
Identification of Microbes in Healthy Lungs Sheds Light on Cystic Fibrosis
STANFORD, Calif. — Healthy people's lungs are home to a diverse community of microbes that differs markedly from the …
Sequences 
10/29/13 
★★ 
Passing the Gac
Recent years have seen significant outbreaks of listeriosis on both sides of the Atlantic. Although the disease can usually …
Neutrophils 
1/31/12 
Exposure to Common Environmental Bacteria May Be Source of Some Allergic Inflammation
Could some cases of asthma actually be caused by an allergic reaction to a common environmental bacteria? New research …
Williams 
5/17/10 
★★★ 
New 'Tree of Life' Established for One of the Largest Groups of Bacteria
A new "tree of life" has been constructed by researchers at the Virginia Bioinformatics Institute (VBI) at Virginia Tech …
Haller 
4/26/12 
Invisible Helpers: How Probiotic Bacteria Protect Against Inflammatory Bowel Diseases
Yoghurt has been valued for centuries for its health-promoting effects. These effects are thought to be mediated by the …
More » 
 
© Newsline Group  |  About  |  Privacy Policy  |  Feedback  |  Mobile