Home  |  Top News  |  Most Popular  |  Video  |  Multimedia  |  News Feeds  |  Feedback
  Medicine  |  Nature & Earth  |  Biology  |  Technology & Engineering  |  Space & Planetary  |  Psychology  |  Physics & Chemistry  |  Economics  |  Archaeology
Top > Biology > New Rat Model for Muscle… >
New Rat Model for Muscle Regeneration After Trauma-related Soft Tissue Injury

Published: January 4, 2013.
By Mary Ann Liebert, Inc./Genetic Engineering News
http://www.liebertpub.com

New Rochelle, NY, January 3, 2013—Penetrating soft tissue injuries that may be caused by bullet wounds or motor vehicle accidents, or exposure to explosive devices in military settings, can cause muscle loss resulting in functional disability and cosmetic deformity. Efforts underway to develop tissue engineering solutions to repair and replace damaged and lost muscle will benefit greatly from the availability of robust animal models to test these innovative therapeutic strategies. A new rat model that simulates traumatic or surgical muscle tissue loss in humans is described in an article in BioResearch Open Access, a bimonthly peer-reviewed open access journal from Mary Ann Liebert, Inc., publishers. The article is available free on the BioResearch Open Access website.

Xiaowu Wu, MD, Benjamin T. Corona, PhD, Xiaoyu Chen, PhD, and Thomas J. Walters, PhD, United States Army Institute of Surgical Research (Fort Sam Houston, TX), Wake Forest Institute for Regenerative Medicine (Winston-Salem, NC), and University of Texas Health Science Center at San Antonio, provide a detailed description of the methods used to create an animal model with approximately 20% volumetric muscle loss (VML) from the middle third of the tibialis anterior muscle. The authors demonstrate successful repair of the injury using a biological scaffold and present their findings in "A Standardized Rat Model of Volumetric Muscle Loss Injury for the Development of Tissue Engineering Therapies."


Show Reference »


Translate this page: Chinese French German Italian Japanese Korean Portuguese Russian Spanish


 
All comments are reviewed before being posted. We cannot accept messages that refer a product, or web site.If you are looking for a response to a question please use our another feedback page.
Related »

Pax3 
7/5/11 
Crucial Role for Molecule in Muscle Development
By University of East Anglia
Research led by the University of East Anglia has discovered the crucial role of a molecule in skeletal muscle development. The finding could have implications in the future …
Cells 
7/5/11 
Crucial Role for Molecule in Muscle Development
By University of East Anglia
Research led by the University of East Anglia has discovered the crucial role of a molecule in skeletal muscle development. The finding could have implications in the future …
Cells 
3/31/14 

Self-healing Engineered Muscle Grown in the Laboratory
By Duke University
Tissue 
3/12/11 
Nanoscale Whiskers from Sea Creatures Could Grow Human Muscle Tissue
By University of Manchester
Nanoscale whiskers from sea creatures could grow human muscle tissue Minute whiskers of nanoscale dimensions taken from sea creatures could hold the key to creating working human muscle …
Muscle 
4/7/11 
Simple Chemical Cocktail Shows First Promise for Limb Re-growth in Mammals
By American Chemical Society
Move over, newts and salamanders. The mouse may join you as the only animal that can re-grow their own severed limbs. Researchers are reporting that a simple chemical cocktail …
Group 
10/4/10 
Surprise: Scientists Discover That Inflammation Helps to Heal Wounds
By Federation of American Societies for Experimental Biology
A new research study published in The FASEB Journal (http://www.fasebj.org) may change how sports injuries involving muscle tissue are treated, as well as how much patient monitoring is necessary …
Proteins 
12/14/11 
★★★★ 
The Mystery Behind the Building of Muscle
By Wellcome Trust Sanger Institute
Researchers at the Wellcome Trust Sanger Institute have discovered two proteins that are essential for the fusion of muscle cells to build muscle fibres. Their discovery might help us …
Genes 
12/20/12 
Cellular Patterns of Development
By Stowers Institute for Medical Research
KANSAS CITY, MO – For a tiny embryo to grow into an entire fruit fly, mouse or human, the correct genes in each cell must turn on and off …
More » 
 
© Newsline Group  |  About  |  Privacy Policy  |  Feedback  |  Mobile  |  Japanese Edition