Home  |  Top News  |  Most Popular  |  Video  |  Multimedia  |  News Feeds  |  Feedback
  Medicine  |  Nature & Earth  |  Biology  |  Technology & Engineering  |  Space & Planetary  |  Psychology  |  Physics & Chemistry  |  Economics  |  Archaeology
Top > Biology > New Rat Model for Muscle… >

New Rat Model for Muscle Regeneration After Trauma-related Soft Tissue Injury

Published: January 4, 2013.
Released by Mary Ann Liebert, Inc./Genetic Engineering News  

New Rochelle, NY, January 3, 2013—Penetrating soft tissue injuries that may be caused by bullet wounds or motor vehicle accidents, or exposure to explosive devices in military settings, can cause muscle loss resulting in functional disability and cosmetic deformity. Efforts underway to develop tissue engineering solutions to repair and replace damaged and lost muscle will benefit greatly from the availability of robust animal models to test these innovative therapeutic strategies. A new rat model that simulates traumatic or surgical muscle tissue loss in humans is described in an article in BioResearch Open Access, a bimonthly peer-reviewed open access journal from Mary Ann Liebert, Inc., publishers. The article is available free on the BioResearch Open Access website.

Xiaowu Wu, MD, Benjamin T. Corona, PhD, Xiaoyu Chen, PhD, and Thomas J. Walters, PhD, United States Army Institute of Surgical Research (Fort Sam Houston, TX), Wake Forest Institute for Regenerative Medicine (Winston-Salem, NC), and University of Texas Health Science Center at San Antonio, provide a detailed description of the methods used to create an animal model with approximately 20% volumetric muscle loss (VML) from the middle third of the tibialis anterior muscle. The authors demonstrate successful repair of the injury using a biological scaffold and present their findings in "A Standardized Rat Model of Volumetric Muscle Loss Injury for the Development of Tissue Engineering Therapies."

The above story is based on materials provided by Mary Ann Liebert, Inc./Genetic Engineering News.

Translate this page: Chinese French German Italian Japanese Korean Portuguese Russian Spanish

comments powered by Disqus

Related »

Crucial Role for Molecule in Muscle Development
Research led by the University of East Anglia has discovered the crucial role of a molecule in skeletal muscle …
Crucial Role for Molecule in Muscle Development
Research led by the University of East Anglia has discovered the crucial role of a molecule in skeletal muscle …

Self-healing Engineered Muscle Grown in the Laboratory
Nanoscale Whiskers from Sea Creatures Could Grow Human Muscle Tissue
Nanoscale whiskers from sea creatures could grow human muscle tissue Minute whiskers of nanoscale dimensions taken from sea …
Cardiac Muscle Really Knows How to Relax: Potential Cardio-protective Mechanism in Heart
New insight into the physiology of cardiac muscle may lead to the development of therapeutic strategies that exploit an …
Lift Weights to Lower Blood Sugar? White Muscle Helps Keep Blood Glucose Levels Under Control
ANN ARBOR—Researchers in the Life Sciences Institute at the University of Michigan have challenged a long-held belief that whitening …
Surprise: Scientists Discover That Inflammation Helps to Heal Wounds
A new research study published in The FASEB Journal (http://www.fasebj.org) may change how sports injuries involving muscle tissue are …

Discovery of How Newborn Mice Repair Bone Fractures Could Improve Treatments
More » 
© Newsline Group  |  About  |  Privacy Policy  |  Feedback  |  Mobile