Home  |  Top News  |  Most Popular  |  Video  |  Multimedia  |  News Feeds  |  Feedback
  Medicine  |  Nature & Earth  |  Biology  |  Technology & Engineering  |  Space & Planetary  |  Psychology  |  Physics & Chemistry  |  Economics  |  Archaeology
Top > Biology > New Rat Model for Muscle… >
New Rat Model for Muscle Regeneration After Trauma-related Soft Tissue Injury

Published: January 4, 2013.
By Mary Ann Liebert, Inc./Genetic Engineering News
http://www.liebertpub.com

New Rochelle, NY, January 3, 2013—Penetrating soft tissue injuries that may be caused by bullet wounds or motor vehicle accidents, or exposure to explosive devices in military settings, can cause muscle loss resulting in functional disability and cosmetic deformity. Efforts underway to develop tissue engineering solutions to repair and replace damaged and lost muscle will benefit greatly from the availability of robust animal models to test these innovative therapeutic strategies. A new rat model that simulates traumatic or surgical muscle tissue loss in humans is described in an article in BioResearch Open Access, a bimonthly peer-reviewed open access journal from Mary Ann Liebert, Inc., publishers. The article is available free on the BioResearch Open Access website.

Xiaowu Wu, MD, Benjamin T. Corona, PhD, Xiaoyu Chen, PhD, and Thomas J. Walters, PhD, United States Army Institute of Surgical Research (Fort Sam Houston, TX), Wake Forest Institute for Regenerative Medicine (Winston-Salem, NC), and University of Texas Health Science Center at San Antonio, provide a detailed description of the methods used to create an animal model with approximately 20% volumetric muscle loss (VML) from the middle third of the tibialis anterior muscle. The authors demonstrate successful repair of the injury using a biological scaffold and present their findings in "A Standardized Rat Model of Volumetric Muscle Loss Injury for the Development of Tissue Engineering Therapies."


Show Reference »


Translate this page: Chinese French German Italian Japanese Korean Portuguese Russian Spanish


Disclaimer: The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the ScienceNewsline.
Related »

Muscle 
7/12/13 

50-year-old Assumptions About Strength Muscled Aside
By Argonne National Laboratory
Force 
7/10/13 
★★ 

Biceps Bulge, Calves Curve, 50-year-old Assumptions Muscled Aside
By University of Washington
Sox6 
6/3/11 
★★★ 
Role of Gene Regulator in Skeletal Muscles Demonstrated
By Virginia Tech
Fast muscles, such as the thigh muscle in a sprinter, deliver energy quickly but fatigue quickly. Slow muscles, such as the soleus muscle in the lower calf, are less …
Muscle 
6/24/10 
New Principle Discovered for How Muscle Pain Is Signaled
By Expertanswer (Expertsvar in Swedish)
Chronic muscular pain may be linked to a previously unknown principle for how pain signals are transmitted in the human body. This is shown by Umeå University researchers Tuija …
Muscle 
4/2/14 
Sport Makes Muscles And Nerves Fit
By University of Basel
Endurance sport does not only change the condition and fitness of muscles but also simultaneously improves the neuronal connections to the muscle fibers based on a muscle-induced feedback. This …
Grow 
3/12/11 
Nanoscale Whiskers from Sea Creatures Could Grow Human Muscle Tissue
By University of Manchester
Nanoscale whiskers from sea creatures could grow human muscle tissue Minute whiskers of nanoscale dimensions taken from sea creatures could hold the key to creating working human muscle …
Muscle 
4/20/11 
Cardiac Muscle Really Knows How to Relax: Potential Cardio-protective Mechanism in Heart
By Cell Press
New insight into the physiology of cardiac muscle may lead to the development of therapeutic strategies that exploit an inherent protective state of the heart. The research, published by …
Muscle 
4/7/13 
Lift Weights to Lower Blood Sugar? White Muscle Helps Keep Blood Glucose Levels Under Control
By University of Michigan
ANN ARBOR—Researchers in the Life Sciences Institute at the University of Michigan have challenged a long-held belief that whitening of skeletal muscle in diabetes is harmful. In fact, …
More » 

Most Popular - Biology »
CLOCK »
Bioinformatics Profiling Identifies a New Mammalian Clock Gene
SEXUAL »
Best Practices in Communication for the Animal World
MEMORY »
Scientists Identify Critical New Protein Complex Involved in Learning And Memory
CHROMOSOME »
From Liability to Viability: Genes on the Y Chromosome Prove Essential for Male Survival
CAMBRIDGE, Mass. (April 23, 2014) – Despite a well-documented history of dramatic genetic decay, the human Y chromosome has over the course of millions of years of evolution managed …
MATING »
Picky Male Black Widow Spiders Prefer Well-fed Virgins
ScienceNewsline  |  About  |  Privacy Policy  |  Feedback  |  Mobile  |  Japanese
The selection and placement of stories are determined automatically by a computer program. All contents are copyright of their owners except U.S. Government works. U.S. Government works are assumed to be in the public domain unless otherwise noted. Everything else copyright ScienceNewsline.