Home  |  Top News  |  Most Popular  |  Video  |  Multimedia  |  News Feeds  |  Feedback
  Medicine  |  Nature & Earth  |  Biology  |  Technology & Engineering  |  Space & Planetary  |  Psychology  |  Physics & Chemistry  |  Economics  |  Archaeology
Top > Medicine, Health Care > How Do Happiness And Sadness… >
How Do Happiness And Sadness Circuits Contribute to Bipolar Disorder?

Published: January 14, 2013.
By Elsevier
http://www.elsevier.com

Philadelphia, PA, January 14, 2013 – Bipolar disorder is a severe mood disorder characterized by unpredictable and dramatic mood swings between the highs of mania and lows of depression. These mood episodes occur among periods of 'normal mood', termed euthymia.

Prior research has clearly shown that brain emotion circuitry is dysregulated in individuals diagnosed with bipolar disorder. It is thought that these disturbances impair one's ability to control emotion and contribute to mood episodes.

Continuing this line of research, the January 15th issue of Biological Psychiatry reports the results of a study conducted by scientists from Indiana University School of Medicine. These investigators used functional magnetic resonance imaging (fMRI) to investigate which areas of the brain showed abnormal activation while patients in different mood phases of bipolar disorder tried to control their response to emotional and non-emotional material.

This allowed them to analyze brain activation patterns based on patient mood (manic, depressed, or euthymic) and stimuli type (emotion versus no emotion and happy versus sad). Because medication effects on brain activation have been observed in some studies, the researchers recruited only unmedicated volunteers.

They found that bipolar depressed patients abnormally activated brain areas when they had to withhold responses to sad faces. Manic patients, on the other hand, had abnormal activation regardless of whether they were trying to withhold response to sad faces, happy faces or non-emotional material. Even the euthymic bipolar subjects showed abnormal activation of cortical areas of the brain while withholding responses to emotional faces.

These findings suggest that distinct circuit dysfunctions may contribute to different features of emotion dysregulation in bipolar disorder.

Professor and senior author Dr. Amit Anand said, "This study provides important information regarding brain areas that may be important in controlling response to emotional material and the functional abnormalities in these areas in mood disorders."

"It is interesting that subtly different circuits distinguish symptomatic and non-symptomatic patients with bipolar disorder when they are suppressing their happy and sad reactions," commented Dr. John Krystal, Editor of Biological Psychiatry. "These findings may have implications for the refinement of circuit-based treatments for bipolar disorder including neurostimulation and psychotherapy."


Show Reference »


Translate this page: Chinese French German Italian Japanese Korean Portuguese Russian Spanish


 
All comments are reviewed before being posted. We cannot accept messages that refer a product, or web site.If you are looking for a response to a question please use our another feedback page.
Related »

Bipolar 
2/16/11 
Treatment for Manic-depressive Illness Restores Brain Volume Deficits
By Elsevier
Philadelphia, PA, 16 February 2011 - Lithium, introduced in the late 1940's, was the first "wonder drug" in psychiatry. It was the first medication treatment for the manic and …
Bipolar 
10/15/12 
Replicating Risk Genes in Bipolar Disorder
By Elsevier
Philadelphia, PA, October 15, 2012 – One of the biggest challenges in psychiatric genetics has been to replicate findings across large studies. …
Populations 
2/13/14 
Understanding the Basic Biology of Bipolar Disorder
By University of California - Los Angeles
Scientists know there is a strong genetic component to bipolar disorder, but they have had an extremely difficult time identifying the genes that cause it. So, in an effort …
Sinai 
6/5/13 
Neuroimaging May Offer New Way to Diagnose Bipolar Disorder
By The Mount Sinai Hospital / Mount Sinai School of Medicine
MRI may be an effective way to diagnose mental illnesses such as bipolar disorder, according to experts from the Icahn School of Medicine at Mount Sinai. In a landmark …
Sinai 
9/20/11 
Several Common Genetic Variants Found to Be Associated with Mental Illness
By The Mount Sinai Hospital / Mount Sinai School of Medicine
As one of the leaders of an international research consortium, Mount Sinai School of Medicine researchers have discovered that several common genetic variants contribute to a person's risk of …
Osuch 
8/15/13 

Imaging in Mental Health And Improving the Diagnostic Process
By Lawson Health Research Institute
Carbonate 
3/11/14 
★ 

Researchers Closer to Improving Safety, Effectiveness of Lithium Therapy
By University of South Florida (USF Health)
 
12/5/13 

Pre-moxibustion And Moxibustion Prevent Alzheimer's Disease
By Neural Regeneration Research
 
1/23/12 
Selectively Inhibiting PKM2 Starves Cancer Cells
By Rockefeller University Press
Crippling a protein that allows cancer cells to grow when oxygen is scarce causes tumors to regress, according to a study published online on January 23 in the Journal …
 
7/15/10 
Less Salt for Everybody
By Deutsches Aerzteblatt International
Restricting the amount of sodium chloride in food can lower the risk of cardiovascular morbidities. This is the conclusion that Dieter Klaus and colleagues come to in the current …
More » 
 
© Newsline Group  |  About  |  Privacy Policy  |  Feedback  |  Mobile  |  Japanese Edition