Home  |  Top News  |  Most Popular  |  Video  |  Multimedia  |  News Feeds  |  Feedback
  Medicine  |  Nature & Earth  |  Biology  |  Technology & Engineering  |  Space & Planetary  |  Psychology  |  Physics & Chemistry  |  Economics  |  Archaeology
Top > Medicine, Health Care > UCI Neuroscientists Create Fiber-optic Method… >
UCI Neuroscientists Create Fiber-optic Method of Arresting Epileptic Seizures

Published: January 24, 2013.
By University of California - Irvine
http://www.uci.edu

Irvine, Calif., Jan. 24, 2013 — UC Irvine neuroscientists have developed a way to stop epileptic seizures with fiber-optic light signals, heralding a novel opportunity to treat the most severe manifestations of the brain disorder.

Using a mouse model of temporal lobe epilepsy, Ivan Soltesz, Chancellor's Professor and chair of anatomy & neurobiology, and colleagues created an EEG-based computer system that activates hair-thin optical strands implanted in the brain when it detects a real-time seizure.

These fibers subsequently "turn on" specially expressed, light-sensitive proteins called opsins, which can either stimulate or inhibit specific neurons in select brain regions during seizures, depending on the type of opsin.

The researchers found that this process was able to arrest ongoing electrical seizure activity and reduce the incidence of severe "tonic-clonic" events.

"This approach is useful for understanding how seizures occur and how they can be stopped experimentally," Soltesz said. "In addition, clinical efforts that affect a minimum number of cells and only at the time of a seizure may someday overcome many of the side effects and limitations of currently available treatment options."

Study results appear online in Nature Communications.

More than 3 million Americans suffer from epilepsy, a condition of recurrent spontaneous seizures that occur unpredictably, often cause changes in consciousness, and can preclude normal activities such as driving and working. In at least 40 percent of patients, seizures cannot be controlled with existing drugs, and even in those whose seizures are well controlled, the treatments can have major cognitive side effects.

Although the study was carried out in mice, not humans, Soltesz said the work could lead to a better alternative to the currently available electrical stimulation devices.


Show Reference »


Translate this page: Chinese French German Italian Japanese Korean Portuguese Russian Spanish


Disclaimer: The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the ScienceNewsline.
Related »

Vimpat 
3/11/10 
Study Reinforces Role of AED Vimpat (lacosamide) (C-V) as Add-on Treatment for POS
By Cooney Waters Group, Inc.
Atlanta – March 11, 2010 – press release – UCB today announced that the antiepileptic drug (AED) Vimpat (lacosamide) (C-V) demonstrated significantly fewer partial-onset seizures versus placebo in adults …
People 
4/14/11 
New Drug May Reduce Seizures in Epilepsy
By American Academy of Neurology
HONOLULU – A new drug called perampanel appears to significantly reduce seizures in people with hard-to-control epilepsy, according to results of the first clinical trial to test the higher …
Patients 
10/1/10 
Adjunctive Rufinamide Reduces Refractory Partial-onset Seizures
By Wiley-Blackwell
Researchers from the Arkansas Epilepsy Program found treatment with rufinamide results in a significant reduction in seizure frequency compared with placebo, for patients with uncontrolled partial-onset seizures (POS). Details …
Drug 
12/14/11 
★★ 
Study Finds Superior Drug Combo for Difficult-to-control Epilepsy
By University of Washington
A combination of two common drugs, lamotrigine and valproate, is more effective in treating difficult-to control epilepsy than other anti-epileptic regimens, according to a University of Washington report to …
Epilepsy 
11/15/11 
Vascular Risk Linked to Long-term Antiepileptic Drug Therapy
By Wiley-Blackwell
New research reveals that patients with epilepsy who were treated for extended periods with older generation antiepileptic drugs (AEDs) may be at increased risk for developing atherosclerosis, a common …
Years 
6/14/10 
Study Confirms Favorable Long-term Prognosis of Epilepsy
By Wiley-Blackwell
A study conducted by researchers in The Netherlands confirmed that children with idiopathic new-onset epilepsy have a significantly higher rate of remission than those with remote symptomatic epilepsy. Results …
Studies 
4/20/10 
Adverse Drug Effects in Epileptic Patients Not Correlated with Number of Prescribed Medications
By Wiley-Blackwell
Researchers have found that polytherapy with multiple anti-epileptic drugs (AEDs) did not result in greater adverse effects than monotherapy for patients with refractory epilepsy. This observational study also found …
More » 

Most Popular - Medicine »
MARIJUANA »
Casual Marijuana Use Linked to Brain Abnormalities in Students
CHICAGO --- Young adults who used marijuana only recreationally showed significant abnormalities in two key brain regions that are important in emotion and motivation, scientists report. The study was …
TUMORS »
The Immune System's Redesigned Role in Fighting Cancerous Tumors
LOS ANGELES (March 11, 2014) – Researchers in the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute eradicated solid tumors in laboratory mice using a novel combination of two targeted agents. …
INFLUENZA »
Ginseng Can Treat And Prevent Influenza And RSV, Researcher Finds
ATLANTA--Ginseng can help treat and prevent influenza and respiratory syncytial virus (RSV), a respiratory virus that infects the lungs and breathing passages, according to research findings by a scientist …
MUTATIONS »
Applying Math to Biology: Software Identifies Disease-causing Mutations in Undiagnosed Illnesses
(SALT LAKE CITY)–A computational tool developed at the University of Utah (U of U) has successfully identified diseases with unknown gene mutations in three separate cases, U of U …
PROTEINS »
MSU Physicists Push New Parkinson's Treatment Toward Clinical Trials
ScienceNewsline  |  About  |  Privacy Policy  |  Feedback  |  Mobile  |  Japanese
The selection and placement of stories are determined automatically by a computer program. All contents are copyright of their owners except U.S. Government works. U.S. Government works are assumed to be in the public domain unless otherwise noted. Everything else copyright ScienceNewsline.