Home  |  Top News  |  Most Popular  |  Video  |  Multimedia  |  News Feeds  |  Feedback
  Medicine  |  Nature & Earth  |  Biology  |  Technology & Engineering  |  Space & Planetary  |  Psychology  |  Physics & Chemistry  |  Economics  |  Archaeology
Top > Medicine, Health Care > Protein Responsible for 'Bad' Blood… >

Protein Responsible for 'Bad' Blood Vessel Growth Discovered

Published: July 17, 2013.
Released by University College London  

The discovery of a protein that encourages blood vessel growth, and especially 'bad' blood vessels – the kind that characterise diseases as diverse as cancer, age-related macular degeneration and rheumatoid arthritis – has been reported in the journal Nature.

The team at the UCL Institute of Ophthalmology discovered the new protein, called LRG1, by screening for mouse genes that are over-expressed in abnormal retinal blood vessels in diseased eyes.

In these diseased retinas the LRG1 protein is expressed by blood vessel endothelial cells, which line blood vessel walls. LRG1 is also present in the eyes of patients with proliferative diabetic retinopathy – a vascular complication of diabetes that can lead to blindness.

The study shows that, in mouse models, LRG1 promotes the growth of blood vessels in a process known as 'angiogenesis'. Conversely, inhibition of LRG1 in mouse models reduces the harmful blood vessel growth associated with retinal disease.

The authors of the study suggest that blocking LRG1's activity is a promising target for future therapy.

Professor John Greenwood, senior author of the research from the UCL Institute of Ophthalmology said: "We have discovered that a secreted protein, LRG1, promotes new blood vessel growth and its inhibition prevents pathological blood vessel growth in ocular disease.

"Our findings suggest that LRG1 has less of a role in normal blood vessel growth and so may be particularly applicable to 'bad' blood vessel growth. This makes LRG1 an especially attractive target for therapeutic intervention in conditions where vessel growth contributes to disease."

Angiogenesis is an essential biological process that is required for development, reproduction and the repair of damaged tissues. However angiogenesis also plays a major role in many diseases where new vessel growth can be harmful.

For example, in the retina uncontrolled and irregular blood vessel growth in diseases such as age-related macular degeneration and diabetic retinopathy can result in a catastrophic loss of vision. Another example is the growth of cancerous solid tumours, which are dependent on the proliferation of new blood vessels. Angiogenesis is also an important feature of rheumatoid arthritis, where it contributes to the inflammation of the joint.

In previous studies, many signaling molecules have been identified that control angiogenesis, with the secreted protein vascular endothelial growth factor (VEGF) being considered as the master regulator. Therapeutic targeting of VEGF has resulted in improved outcomes in eye diseases with vascular complications and in some cancers but it is clear that additional therapeutic targets need to be identified.

The mechanism through which LRG1 promotes angiogenesis is by modifying the signalling of a multifunctional secreted growth factor called transforming growth factor beta (TGF-beta). TGF-beta regulates both the maintenance of normal healthy blood vessels, and the unwanted growth of harmful blood vessels, but precisely how it promotes two opposing outcomes is a biological paradox.

This study indicates that in the retinal diseases investigated LRG1 production is 'turned on' in blood vessels. This causes a switch in TGF-beta signalling away from a normal vessel maintenance pathway towards a pathway that promotes the growth of new harmful blood vessels.

Professor Stephen Moss, senior author from the UCL Institute of Ophthalmology said: "Genetic studies have revealed that the gene that codes for LRG1 is conserved in vertebrates, and this study confirms that mouse and human blood vessels express LRG1.

"We predict, therefore, that abnormal blood vessel growth is also a conserved process and that the role of LRG1 is equally applicable to human pathological angiogenesis."

He added: "Work is already underway to develop a therapeutic antibody that targets LRG1."




The above story is based on materials provided by University College London.

Translate this page: Chinese French German Italian Japanese Korean Portuguese Russian Spanish


comments powered by Disqus


Related »

Tumour 
3/20/14 
★★ 
New Type of Cell Communication Regulates Blood Vessel Formation And Tumor Growth
When tumours grow, new blood vessels are formed that deliver oxygen and nutrients to the tumour cells. A research …
Growth 
2/16/12 
★ 
New Ability to Regrow Blood Vessels Holds Promise for Treatment of Heart Disease
University of Texas at Austin researchers have demonstrated a new and more effective method for regrowing blood vessels in …
Factors 
2/20/14 
Bioengineered Growth Factors Lead to Better Wound Healing
When we are wounded, our bodies naturally begin a process of repair of the damaged tissue. This process is …
Tumour 
5/4/12 
Scientists Aim to Kill Lung Tumors
Lung cancer is the leading cause of cancer death throughout the world. Standard treatment methods do not usually result …
Blood 
8/18/14 
★★★ 
Proteins Critical to Wound Healing Identified
Mice missing two important proteins of the vascular system develop normally and appear healthy in adulthood, as long as …
Cells 
4/6/10 
The Immune System’s Guard Against Cancer
The connection with the blood circulatory system is a significant step in the development of cancer. Within the tissue …
Rasip1 
5/13/11 
UT Southwestern Researchers Find Protein That Might Be Key to Cutting Cancer Cells' Blood Supply
DALLAS – May 12, 2011 – UT Southwestern Medical Center researchers have discovered a protein that guides blood vessel …
Blood 
11/10/14 
Major Blood Vessel Constrictor Contributes to Vision Loss in Premies
AUGUSTA, Ga. - A gene known to play a major role in constricting blood vessels also appears to be …
Therapies 
1/31/15 
Scientists Home in on Reasons Behind Cancer Drug Trial Disappointment
Scientists based at the University of Helsinki, Finland, have discovered a 'hidden' mechanism which could explain why some cancer …
Mechanical 
10/24/11 

Mechanical Stress Can Help Or Hinder Wound Healing Depending on Time of Application
Tumours 
8/13/13 
★★ 
More Than Just a Kinase: CDK6 in Cancer
Cancer in humans is frequently associated with unusually high amounts of one or more proteins responsible for controlling the …
More » 
 
© Newsline Group  |  About  |  Privacy Policy  |  Feedback  |  Mobile