Home  |  Top News  |  Most Popular  |  Video  |  Multimedia  |  News Feeds  |  Feedback
  Medicine  |  Nature & Earth  |  Biology  |  Technology & Engineering  |  Space & Planetary  |  Psychology  |  Physics & Chemistry  |  Economics  |  Archaeology
Top > Medicine, Health Care > Cancer-killing Cells Controlled by Epigenetic… >

Cancer-killing Cells Controlled by Epigenetic Process, New Study Shows

Published: September 24, 2013.
Released by University of Southern California - Health Sciences  

Natural killer (NK) cells in the human body can kill and contain viruses and cancerous tumors, and a new study from the University of Southern California (USC) describes for the first time how those cells can be manipulated by epigenetics. The discovery, detailed in the Proceedings of the National Academy of Sciences, paves the way for developing more effective cancer drugs.

"Natural killer cells are very attractive targets for immunotherapy because they are able to kill tumor cells," said Si-Yi Chen, M.D., Ph.D., a faculty member of the USC Norris Comprehensive Cancer Center and senior author of the study. "While scientists all around the world are working on developing new drugs using NK cells, none of the drugs in development focuses on epigenetic regulation of the cells. Our study describes how an epigenetic process involving the enzyme MYSM1 plays a critical role in the development of natural killer cells."

Epigenetics involve biochemical changes in the body that directly affect DNA, turning some genes on and turning others off. MYSM1 is an enzyme in the body's immune system that turns genes on and off by modifying proteins called histones embedded in DNA.

Through a series of experiments in mice, Chen and his colleagues demonstrate that MYSM1 is required for natural killer cells to mature and function properly.

"We found that MYSM1 creates access to proteins that enhance gene transcription and, ultimately, the maturation of natural killer cells themselves," said Vijayalakshmi Nandakumar, a Ph.D. student at the Keck School of Medicine of USC and the study's first author. "To date, there are no elaborate reports linking an epigenetic phenomenon to natural killer cell development. More importantly, unlike conventional therapies, NK cell-based therapies have shown to be more effective against metastasis. We believe cancer drugs targeting this pathway could be a viable option for future immunotherapies."




The above story is based on materials provided by University of Southern California - Health Sciences.

Translate this page: Chinese French German Italian Japanese Korean Portuguese Russian Spanish


comments powered by Disqus


Related »

Ips 
1/3/13 
Japanese Team Creates Cancer-specific Killer T Cells from Induced Pluripotent Stem Cells
Researchers from the RIKEN Research Centre for Allergy and Immunology in Japan report today that they have succeeded for …
Cells 
2/26/12 
How to Rescue the Immune System
In a study published in Nature Medicine, Loyola researchers report on a promising new technique that potentially could turn …
Cells 
9/5/14 
Synthetic Messenger Boosts Immune System
When a pathogen attacks a healthy cell in the body, T lymphocytes are tasked with identifying and destroying the …
Cells 
4/8/14 
Montreal Researchers Explain How Our Immune System Kills Abnormal Blood Cells
A team of researchers at the IRCM, led by André Veillette, MD, explains how our immune system kills abnormal …
Cells 
2/6/12 
How Autoreactive T Cells Slip Through the Cracks
Immune cells capable of attacking healthy organs "see" their targets differently than do protective immune cells that attack viruses, …
Steroids 
9/11/13 
★★ 
Study Gives New Hope for Women Suffering from Recurrent Miscarriage
A team of researchers, led by the University of Warwick, have published new data that could prove vital for …
Th2 
7/13/10 
Interferon Might Help Asthma Patients Breathe Easier, UT Southwestern Study Suggests
DALLAS – July 15, 2010 – An immune-system protein already used to treat diseases like multiple sclerosis, hepatitis C …
More » 
 
© Newsline Foundation  |  About  |  Privacy Policy  |  Feedback  |  Mobile