Home  |  Top News  |  Most Popular  |  Video  |  Multimedia  |  News Feeds  |  Feedback
  Medicine  |  Nature & Earth  |  Biology  |  Technology & Engineering  |  Space & Planetary  |  Psychology  |  Physics & Chemistry  |  Economics  |  Archaeology
Top > Medicine, Health Care > Weight Loss Through the Use… >

Weight Loss Through the Use of Intestinal Barrier Sleeves

Published: October 10, 2013.
Released by Helmholtz Zentrum München - German Research Center for Environmental Health  

Bariatric surgeries, such as a gastric bypass, are currently the most effective anti-obesity therapies. They also lead to a reduced insulin resistance. However, the pitfall of these surgical interventions is that they are highly invasive and often permanent procedures. An international team of scientists led by Dr. Kirk Habegger, Metabolic Disease Institute, University of Cincinnati, and Prof. Dr. Matthias Tschöp, Scientific Director of the Helmholtz Diabetes Center (HDC) at the Helmholtz Zentrum München (HMGU), Partner of the German Center for Diabetes Research (DZD), have now developed an equally efficient but less invasive surgical method, thus paving the way for the development of novel safe and efficient anti-obesity therapies.

In their study, a flexible tube, called a DES (duodenal-endoluminal sleeve), was placed in the small intestine. Tschöp, Habegger, and colleagues observed that this intervention in an animal model potently corrects obesity while improving glucose metabolism. The metabolic benefits of this novel surgical intervention seem to be mediated via reduced nutrient absorption in the intestinal lumen and reactive mucous membrane growth in the other intestinal sections, a shift which may lead to improved nutrient utilization. The intervention carries the great advantage that it is less invasive and removable at any time.

The method is consequently seen as a promising approach to treat obesity and diabetes. Further studies now aim to clarify which influence this novel surgical technique has on the complex neuroendocrine network that controls energy metabolism. The long-term goal based on such better understanding is to optimize devices to the level where they can be used successfully in humans, potentially in combination with hormone based drug therapies. (Also see press release "Enhancing weight loss: Gastric banding with hormone therapy.")

The numerous conditions associated with overweight and obesity, such as type 2 diabetes, are among the major widespread diseases in Germany. They are the focus of the research at the Helmholtz Zentrum München.




The above story is based on materials provided by Helmholtz Zentrum München - German Research Center for Environmental Health.

Translate this page: Chinese French German Italian Japanese Korean Portuguese Russian Spanish


comments powered by Disqus


Related »

Energy 
1/18/11 
Selective Estrogen Signaling Key to Postmenopausal Risk of Obesity
The hormone estradiol-17-beta is a key reproductive hormone. However, it also contributes to the regulation of energy balance and …
Resistance 
10/11/12 
Target for Obesity Drugs Comes into Focus
ANN ARBOR—Researchers at the University of Michigan have determined how the hormone leptin, an important regulator of metabolism and …
Txnip 
4/20/11 
Einstein Researchers Find Link Between Brain Molecule And Obesity And Diabetes
April 19, 2011 – (BRONX, NY) – The brain's hypothalamus plays a key role in obesity and one of …
Nsaids 
8/14/14 
NSAIDs May Lower Breast Cancer Recurrence Rate in Overweight And Obese Women
PHILADELPHIA — Recurrence of hormone-related breast cancer was cut by half in overweight and obese women who regularly used …
Fxr 
4/22/14 
Researchers Identify a Mechanism Linking Bariatric Surgery to Health Benefits
Bariatric surgery has positive effects not only on weight loss but also on diabetes and heart disease. Researchers at …
Important 
5/9/12 
Hot Sauce Ingredient Reduces 'Beer Belly' Fat as a Weight-loss Surgery Alternative
BOSTON, MA—According to research from Brigham and Women's Hospital (BWH), the ingredient that gives hot sauce its heat could …
Php 
2/5/14 
Obesity Treatment Using Stem Cells Is the Topic of 2013's Most-visited News Release on EurekAlert!
For the second year in a row, obesity research features prominently in the group of 10 most-visited news releases …
More » 
 
© Newsline Group  |  About  |  Privacy Policy  |  Feedback  |  Mobile