Home  |  Top News  |  Most Popular  |  Video  |  Multimedia  |  News Feeds  |  Feedback
  Medicine  |  Nature & Earth  |  Biology  |  Technology & Engineering  |  Space & Planetary  |  Psychology  |  Physics & Chemistry  |  Economics  |  Archaeology
Top > Medicine, Health Care > Stomach Cells Naturally Revert to… >
Stomach Cells Naturally Revert to Stem Cells

Published: October 10, 2013.
By Washington University School of Medicine
http://www.medicine.wustl.edu

New research has shown that the stomach naturally produces more stem cells than previously realized, likely for repair of injuries from infections, digestive fluids and the foods we eat.

Stem cells can make multiple kinds of specialized cells, and scientists have been working for years to use that ability to repair injuries throughout the body. But causing specialized adult cells to revert to stem cells and work on repairs has been challenging.

Scientists from Washington University School of Medicine in St. Louis and Utrecht Medical Center in the Netherlands report in the new study that a class of specialized cells in the stomach reverts to stem cells more often than they thought.

"We already knew that these cells, which are called chief cells, can change back into stem cells to make temporary repairs in significant stomach injuries, such as a cut or damage from infection," said Jason Mills, MD, PhD, associate professor of medicine at Washington University. "The fact that they're making this transition more often, even in the absence of noticeable injuries, suggests that it may be easier than we realized to make some types of mature, specialized adult cells revert to stem cells."

The findings are published Oct. 10 in Cell.

Chief cells normally produce digestive fluids for the stomach. Mills studies their transformation into stem cells for injury repair. He also is investigating the possibility that the potential for growth unleashed by this change may contribute to stomach cancers.

In the new report, Mills, graduate student Greg Sibbel and Hans Clevers, MD, PhD, a geneticist at Utrecht Medical Center, identify markers that show a small number of chief cells become stem cells even in the absence of serious injury.

If a significant injury is introduced in cell cultures or in animal models, more chief cells become stem cells, making it possible to fix the damage.

"Chief cells normally are big factories with elaborate networks of tubing and secretory mechanisms for making and secreting digestive juices," said Mills, the associate director of Washington University's Digestive Diseases Center. "That all has to be dismantled and recycled so the chief cell can become a stem cell. It's a remarkable change."

Mills' other goals include learning if the chief cells' transformations are triggered by signals sent by injured tissue, by damage sensors on the chief cells or by some combination of these methods.


Show Reference »


Translate this page: Chinese French German Italian Japanese Korean Portuguese Russian Spanish


 
All comments are reviewed before being posted. We cannot accept messages that refer a product, or web site.If you are looking for a response to a question please use our another feedback page.
Related »

Cancer 
4/12/11 
★★★★ 
Scientists Identify a Surprising New Source of Cancer Stem Cells
By Whitehead Institute for Biomedical Research
FINDINGS: Certain differentiated cells in breast tissue can spontaneously convert to a stem-cell-like state, according to Whitehead Institute researchers. Until now, scientific dogma has stated that differentiation is a …
Brain 
1/20/11 
Go Figure: Math Model May Help Researchers with Stem Cell, Cancer Therapies
By University of Florida
The difficult task of sorting and counting prized stem cells and their cancer-causing cousins has long frustrated scientists looking for new ways to help people who have progressive diseases. …
Cancer 
3/18/11 
Stem Cells May Be Key to Understanding the Origins of Colon Cancer And Detecting Relapse
By Institute for Research in Biomedicine (IRB Barcelona)
Colorectal cancer cells trigger a set of genes similar to those found in intestinal stem cells, scientists at the Institute for Research in Biomedicine (IRB Barcelona) have found. The …
Cells 
11/14/12 
Stem Cell Finding Could Advance Immunotherapy for Lung Cancer
By University of Cincinnati Academic Health Center
CINCINNATI—A University of Cincinnati (UC) Cancer Institute lung cancer research team reports that lung cancer stem cells can be isolated—and then grown—in a preclinical model, offering a new avenue …
Cells 
1/6/14 
Cedars-Sinai Researchers Target Cancer Stem Cells in Malignant Brain Tumors
By Cedars-Sinai Medical Center
LOS ANGELES (Jan. 6, 2014) – Researchers at the Cedars-Sinai Maxine Dunitz Neurosurgical Institute and Department of Neurosurgery identified immune system targets on cancer stem cells – cells from …
Cells 
4/10/14 
Researchers Identify Transcription Factors Distinguishing Glioblastoma Stem Cells
By Massachusetts General Hospital
The activity of four transcription factors – proteins that regulate the expression of other genes – appears to distinguish the small proportion of glioblastoma cells responsible for the aggressiveness …
Stem 
9/26/13 
Study of 'Sister' Stem Cells Uncovers New Cancer Clue
By Institute of Cancer Research
Scientists have used a brand new technique for examining individual stem cells to uncover dramatic differences in the gene expression levels – which genes are turned 'up' or 'down'– …
More » 
 
© Newsline Group  |  About  |  Privacy Policy  |  Feedback  |  Mobile  |  Japanese Edition
All contents are copyright of their owners except U.S. Government works. U.S. Government works are assumed to be in the public domain unless otherwise noted. Everything else copyright ScienceNewsline.