Home  |  Top News  |  Most Popular  |  Video  |  Multimedia  |  News Feeds  |  Feedback
  Medicine  |  Nature & Earth  |  Biology  |  Technology & Engineering  |  Space & Planetary  |  Psychology  |  Physics & Chemistry  |  Economics  |  Archaeology
Top > Medicine, Health Care > Researchers Identify Gene Variant That… >
Researchers Identify Gene Variant That Raises Risk for Colorectal Cancer from Eating Processed Meat

Published: October 24, 2013.
By University of Southern California
http://www.usc.edu

A common genetic variant that affects 1 in 3 people significantly increases the risk of colorectal cancer from the consumption of red meat and processed meat, according to a study presented today at the annual American Society of Human Genetics 2013 meeting, the largest gathering of human geneticists in the world.

In addition to identifying a gene that raises risk for colorectal cancer from eating red or processed meat, the study — the first to identify the interactions of genes and diet on a genome-wide scale — also reveals another specific genetic variation that appears to modify whether eating more vegetables, fruits and fiber actually lowers your colorectal cancer risk.

"Diet is a modifiable risk factor for colorectal cancer. Our study is the first to understand whether some individuals are at higher or lower risk based on their genomic profile. This information can help us better understand the biology and maybe in the future lead to targeted prevention strategies," said lead author Jane Figueiredo, Ph.D., Assistant Professor of Preventive Medicine at the Keck School of Medicine of USC.

"But we are not saying that if you don't have the genetic variant that you should eat all the red meat you'd like," Figueiredo added. "People with the genetic variant allele have an even higher increased risk of colorectal cancer if they consume high levels of processed meat, but the baseline risk associated with meat is already pretty bad."

We've all heard reports about how certain foods may lower or raise the risk for certain diseases, such as cancer. But how our personal genetic variations modify the effects of diet on disease has not yet been thoroughly investigated, said senior author Ulrike Peters, Ph.D., M.P.H, of the Fred Hutchinson Cancer Research Center's Public Health Sciences Division.

The researchers systematically searched the more than 2.7 million genetic sequences for interactions with consumption of red and processed meat. The study looked at 9,287 patients with colorectal cancer and a control group of 9,117 individuals without cancer.

The risk of colorectal cancer associated with processed meat was significantly higher among people with the genetic variant rs4143094, the study shows. This variant is located on the same chromosome 10 region that includes GATA3, a transcription factor gene previously linked to several forms of cancer. The transcription factor encoded by this gene normally plays a role in the immune system, but carries this genetic variant in about 36 percent of the population.

The researchers speculate that the digestion of processed meat may promote an immunological or inflammatory response that may trigger tumor development. The GATA3 transcription factor normally would help suppress the immunological or inflammatory response. However, if the GATA3 gene region contains a genetic variant, it may encode a dysregulated transcription factor that impacts its ability to suppress the response.

But other genetic vatiants may be beneficial: On chromosome 8, another statistically significant diet-gene interaction was found in variant rs1269486. For people with this variant, eating your fruits and veggies may be even better for you when it comes to colorectal cancer risk, the research shows.

The study is part of an ongoing collaboration among multiple institutions worldwide, the international NIH-funded Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO).

"GECCO aims to continue to discover additional colorectal cancer-related variants by investigating how genetic variants are modified by other environmental and lifestyle risk factors, including biomarkers as well as how they influence patient treatment response and survival," Peters said, emphasizing how much further research is required to uncover the specific mechanisms by which genes modulate the intake of certain foods on colorectal cancer risk.

Colorectal cancer is a multi-factorial disease attributed to lifestyle, environmental and genetic causes, and the third leading cause of cancer death in both men and women across most racial groups. Over 30 genetic susceptibility alleles for colorectal cancer have been pinpointed throughout the genome. They include rare variants that have a strong impact on risk and common variants that are low risk.

"Colorectal cancer is a disease that is strongly influenced by certain types of diets," Figueiredo said. "We're showing the biological underpinnings of these correlations, and understand whether genetic variation may make some people more or less susceptible to certain carcinogens in food, which may have future important implications for prevention and population health."


Show Reference »


Translate this page: Chinese French German Italian Japanese Korean Portuguese Russian Spanish


Disclaimer: The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the ScienceNewsline.
Related »

Colorectal 
10/24/13 
Gene-diet Interaction May Help Explain Link Between Eating Meat & Colorectal Cancer Risk
By American Society of Human Genetics
A newly discovered potential gene-diet interaction for colorectal cancer was reported today (Thursday, Oct. 24) at the American Society of Human Genetics 2013 meeting in Boston. The interaction may …
Cancer 
11/8/10 
Statins Did Not Reduce Colorectal Cancer in WHI Analysis
By American Association for Cancer Research
PHILADELPHIA — The use of statins among a group of postmenopausal women did not reduce the risk for colorectal cancer, according to the results of a prospective analysis of …
Risk 
4/19/10 
Gene Test Shows Who Could Benefit from Statins to Reduce Colon Cancer Risk: Study
By University of Michigan Health System
ANN ARBOR, Mich. — A genetic test can help determine in which patients cholesterol-lowering statin drugs might have the most benefit in also reducing the risk of colorectal cancer, …
Colorectal 
9/30/13 
CU Cancer Center Study: Young Patients with Metastatic Colorectal Cancer at Higher Risk
By University of Colorado Denver
Younger patients with colorectal cancer that has spread to other parts of the body represent a high-risk group that is less likely to respond to treatment. Colorectal cancer in …
Risk 
10/18/10 
Statin Use Associated with Statistically Significant Reduction in Colorectal Cancer
By American College of Gastroenterology
San Antonio, Texas, October 18, 2010 – A systematic review of the medical literature supports the hypothesis that statins, cholesterol‐lowering drugs used to prevent cardiac problems, are associated with …
Colorectal 
4/17/14 
New Gene Variant Found Increases the Risk of Colorectal Cancer from Eating Processed Meat
By PLOS
A common genetic variant that affects one in three people appears to significantly increase the risk of colorectal cancer from the consumption of processed meat, according to study published …
Colorectal 
4/21/10 
Research Team Discovers Genetic Variance in Cancer Protection from Statin Drugs
By New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
NEW YORK (April 21, 2010) -- Researchers at NewYork-Presbyterian Hospital/Weill Cornell Medical Center have discovered why statins -- popular drugs that lower cholesterol and appear to protect against colorectal …
Colorectal 
4/19/10 
Statins Do Not Protect Patients Against Risk of Colorectal Adenoma
By American Association for Cancer Research
WASHINGTON, D.C. — Statins did not protect patients against colorectal adenomas, which are benign precursors of colorectal cancer, according to results of a secondary analysis of the Adenoma Prevention …
Younger 
9/28/13 
Young Patients with Metastatic Colorectal Cancer Are at High Risk of Disease Progression And Death
By ECCO-the European CanCer Organisation
Younger patients with colorectal cancer that has spread (metastasised) to other parts of the body represent a high-risk group that is less likely to respond to anti-cancer treatments. Their …
More » 

Most Popular - Medicine »
TUMORS »
The Immune System's Redesigned Role in Fighting Cancerous Tumors
LOS ANGELES (March 11, 2014) – Researchers in the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute eradicated solid tumors in laboratory mice using a novel combination of two targeted agents. …
MARIJUANA »
Casual Marijuana Use Linked to Brain Abnormalities in Students
CHICAGO --- Young adults who used marijuana only recreationally showed significant abnormalities in two key brain regions that are important in emotion and motivation, scientists report. The study was …
IRON »
Study: Iron Consumption Can Increase Risk for Heart Disease
INFLUENZA »
Ginseng Can Treat And Prevent Influenza And RSV, Researcher Finds
ATLANTA--Ginseng can help treat and prevent influenza and respiratory syncytial virus (RSV), a respiratory virus that infects the lungs and breathing passages, according to research findings by a scientist …
PROTEINS »
MSU Physicists Push New Parkinson's Treatment Toward Clinical Trials
ScienceNewsline  |  About  |  Privacy Policy  |  Feedback  |  Mobile  |  Japanese
The selection and placement of stories are determined automatically by a computer program. All contents are copyright of their owners except U.S. Government works. U.S. Government works are assumed to be in the public domain unless otherwise noted. Everything else copyright ScienceNewsline.