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Hyperactivity in Brain May Explain Multiple Symptoms of Depression

Published: February 28, 2012.
By University of California - Los Angeles

But the combination of so many symptoms suggested to UCLA researchers that the multiple symptoms of depression may be linked to a malfunction involving brain networks — the connections that link different brain regions. They measured the synchronization of electrical signals from the brain — brain waves — to study networks among the different brain regions.

Brain rhythms in some of these networks regulate the release of serotonin and other brain chemicals that help control mood, said Leuchter, who is also the director of UCLA's Laboratory of Brain, Behavior, and Pharmacology and chair of the UCLA Academic Senate. It is possible that a primary effect of antidepressant treatment is to 'repair' the brain's electrical connections and that normalizing brain connectivity is a key step in recovery from depression.

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