Home  |  Top News  |  Most Popular  |  Video  |  Multimedia  |  News Feeds  |  Feedback
  Medicine  |  Nature & Earth  |  Biology  |  Technology & Engineering  |  Space & Planetary  |  Psychology  |  Physics & Chemistry  |  Economics  |  Archaeology
Top > Medicine, Health Care >
2 Y Genes Can Replace the Entire Y Chromosome for Assisted Reproduction in Mice

Published: November 21, 2013.
By University of Hawaii at Manoa

The Y chromosome is a symbol of maleness, present only in males and encoding genes important for male reproduction. But live mouse offspring can be generated with assisted reproduction using germ cells from males with the Y chromosome contribution limited to only two genes: the testis determinant factor Sry and the spermatogonial proliferation factor Eif2s3y .

Because the overall efficiency of ROSI with two Y genes was lower than with regular, fertile mice, the researchers then looked to see whether the addition of other Y genes could improve it.

"Most of the mouse Y chromosome genes are necessary for normal fertilization," Ward said. It may be possible to eliminate the mouse Y chromosome altogether if appropriate replacements are made for those two genes.

Read Full Story »


Chromosome, Mouse, Reproduction, Genes, Ward, Male, Cells, Rosi, Normal, Mice, Immature, Germ, Fertilization, Technologies, Sry, Sperm, Researchers, Present, Offspring, Males, Live, Infertility, Human, Factor, Eif2s3y, Contribution, …

Cluster Centroids (Superclass Keywords)

Sry, Genes, Frey, Chromosome, Aphids, Carotenoids, Reproduction, Genetic, Alteration, Code, Clitoris, Rosi, Puppy, Weiss, Male, Blencowe, Fungi, Tana, Messages, Fungi-To-Aphid, Aphid, Transfer, Moran, Campos, Switch, Ward, Fertilization, Eif2s3y, Germ, Color, Master, Generate, Splicing, Daughter, Mouse, Immature, Testicles, Human, Sexual, Animal, Cryptorchid, Normal, Father, Bulldog, Reversal, Development, Reproductive, Competencies, Puppies, Gene, …

More news from University of Hawaii at Manoa

Overpopulation: The Transparent Elephant in the Room Causing Crucial Modern Crises
17 March 2014
Where Have All the Codfish Gone?
26 February 2014
Marine Tubeworms Need Nudge to Transition from Larvae State
09 January 2014
An Ecosystem-based Approach to Protect the Deep Sea from Mining
05 December 2013
Antarctic Fjords Are Climate-sensitive Hotspots of Diversity in a Rapidly Warming Region
03 December 2013
High-energy Physicists Predict New Family of Four-quark Objects
08 November 2013
Long-term Study Links Box Jellyfish Abundance, Environmental Variability at Waikiki Beach
23 October 2013

Related »

Boy Interrupted: Y-chromosome Mutations Reveal Precariousness of Male Development
By Case Western Reserve University
The idea that men and women are fundamentally different from each other is widely accepted. And throughout the world, this has created distinct ideas about which social and physical …

First French Bulldog with Sex Reversal Identified in Spain
By FECYT - Spanish Foundation for Science and Technology
U of T Researchers Crack 'Splicing Code,' Solve a Mystery Underlying Biological Complexity
By University of Toronto
TORONTO, ON – Researchers at the University of Toronto have discovered a fundamentally new view of how living cells use a limited number of genes to generate enormously complex …
Aphids Evolved Special, Surprising Talents
By National Science Foundation
Contrary to popular belief, aphids are not just sap-sucking, plant-destroying enemies of agriculture. In fact, these pests are genetic pioneers that evolved two unique traits, according to a study …
More » 

Most Popular - Medicine »
Casual Marijuana Use Linked to Brain Abnormalities in Students
CHICAGO --- Young adults who used marijuana only recreationally showed significant abnormalities in two key brain regions that are important in emotion and motivation, scientists report. The study was …
The Immune System's Redesigned Role in Fighting Cancerous Tumors
LOS ANGELES (March 11, 2014) – Researchers in the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute eradicated solid tumors in laboratory mice using a novel combination of two targeted agents. …
Research Gives New Insights into Rare Disease of the Inner Ear
A new study has shed light on the factors likely to lead to the development of a rare condition affecting the inner ear. In the most comprehensive study …
Breaking Bad Mitochondria
Regenerating Muscle in Duchenne Muscular Dystrophy: Age Matters
ScienceNewsline  |  About  |  Privacy Policy  |  Feedback  |  Mobile  |  Japanese
The selection and placement of stories are determined automatically by a computer program. All contents are copyright of their owners except U.S. Government works. U.S. Government works are assumed to be in the public domain unless otherwise noted. Everything else copyright ScienceNewsline.