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SDSC Resources, Expertise Used in Genomic Analysis of 115 Year-old Woman

Published: April 30, 2014.
By University of California - San Diego
http://www.ucsd.edu

A team of researchers investigating the genome of a healthy supercentenarian since 2011 has found many somatic mutations – permanent changes in cells other than reproductive ones – that arose during the woman's lifetime. Led by Erik Sistermans and Henne Holstege from the VU University Medical Center in Amsterdam, the team recently published its findings in the journal Genome Research as reported by GenomeWeb.


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biology
Physicists Solve Longstanding Puzzle of How Moths Find Distant Mates
The way in which male moths locate females flying hundreds of meters away has long been a mystery to scientists. Researchers know the moths use pheromones to locate their mates. Yet when these chemical odors are widely dispersed in a windy, turbulent atmosphere, the insects still manage to fly in the right direction over hundreds of meters with only random puffs of their mates' pheromones spaced tens of seconds apart to guide them.
space
POLARBEAR Detects B-modes in the Cosmic Microwave Background
Cosmologists have made the most sensitive and precise measurements yet of the polarization of the cosmic microwave background. The report, published October 20 in the Astrophysical Journal, marks an early success for POLARBEAR, a collaboration of more than 70 scientists using a telescope high in Chile's Atacama desert designed to capture the universe's oldest light.
medicine
PTPRZ-MET Fusion Protein: A New Target for Personalized Brain Cancer Treatment
Researchers at the University of California, San Diego School of Medicine have identified a new fusion protein found in approximately 15 percent of secondary glioblastomas or brain tumors. The finding offers new insights into the cause of this cancer and provides a therapeutic target for personalized oncologic care. The findings were published this month in the online edition of Genome Research.
biology
Moderate Levels of 'Free Radicals' Found Beneficial to Healing Wounds
Long assumed to be destructive to tissues and cells, "free radicals" generated by the cell's mitochondria—the energy producing structures in the cell—are actually beneficial to healing wounds.
biology
Researchers Unfold New Details About a Powerful Protein
Using X-rays and neutron beams, a team of researchers from the University of California, San Diego School of Medicine, University of Utah and Oak Ridge National Laboratory have teased out new information about Protein Kinase A (PKA), a ubiquitous master switch that helps regulate fundamental cellular functions like energy consumption and interactions with hormones, neurotransmitters and drugs.
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Blood Cells May Offer Telltale Clues in Cancer Diagnosis
By Dartmouth College
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