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SDSC Resources, Expertise Used in Genomic Analysis of 115 Year-old Woman

Published: April 30, 2014.
By University of California - San Diego
http://www.ucsd.edu

A team of researchers investigating the genome of a healthy supercentenarian since 2011 has found many somatic mutations – permanent changes in cells other than reproductive ones – that arose during the woman's lifetime. Led by Erik Sistermans and Henne Holstege from the VU University Medical Center in Amsterdam, the team recently published its findings in the journal Genome Research as reported by GenomeWeb.


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More news from University of California - San Diego


medicine
Fear, Safety And the Role of Sleep in Human PTSD
The effectiveness of post-traumatic stress disorder (PTSD) treatment may hinge significantly upon sleep quality, report researchers at the University of California, San Diego School of Medicine and Veterans Affairs San Diego Healthcare System in a paper published today in the Journal of Neuroscience.
medicine
Finding Keys to Glioblastoma Therapeutic Resistance
Researchers at the University of California, San Diego School of Medicine have found one of the keys to why certain glioblastomas – the primary form of a deadly brain cancer – are resistant to drug therapy. The answer lies not in the DNA sequence of the tumor, but in its epigenetic signature. These findings have been published online as a priority report in the journal Oncotarget.
nature
Severe Drought Is Causing the Western US to Rise
The severe drought gripping the western United States in recent years is changing the landscape well beyond localized effects of water restrictions and browning lawns. Scientists at Scripps Institution of Oceanography at UC San Diego have now discovered that the growing, broad-scale loss of water is causing the entire western U.S. to rise up like an uncoiled spring.
technology
Researchers Find Security Flaws in Backscatter X-ray Scanners
A team of researchers from the University of California, San Diego, the University of Michigan, and Johns Hopkins University have discovered several security vulnerabilities in full-body backscatter X-ray scanners deployed to U.S. airports between 2009 and 2013.
medicine
New Mouse Model Points to Therapy for Liver Disease
Non-alcoholic fatty liver disease (NAFLD) is a common affliction, affecting almost 30 percent of Americans, with a significant number suffering from its most severe form, called non-alcoholic steatohepatitis or NASH, which can lead to cirrhosis and liver cancer. In recent years, NASH has become the leading cause of liver transplantation.
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Cells 
8/4/10 
Caltech Biologists Discover MicroRNAs That Control Function of Blood Stem Cells
By California Institute of Technology
PASADENA, Calif.—Hematopoietic stem cells provide the body with a constant supply of blood cells, including the red blood cells that deliver oxygen and the white blood cells that make …
Capture 
11/12/12 
On the Hunt for Rare Cancer Cells
By Massachusetts Institute of Technology
Tumor cells circulating in a patient's bloodstream can yield a great deal of information on how a tumor is responding to treatment and what drugs might be more effective …
Leukemia 
5/9/14 
Scientists Decode Epigenetic Mechanisms Distinguishing Stem Cell Function And Blood Cancer
By The Geisel School of Medicine at Dartmouth
Researchers at Dartmouth's Norris Cotton Cancer Center have published results from a study in Cell Reports that discovers a new mechanism that distinguishes normal blood stem cells from blood …
Cells 
1/31/13 
Discovery Opens the Door to a Potential 'Molecular Fountain of Youth'
By University of California - Berkeley
Berkeley — A new study led by researchers at the University of California, Berkeley, represents a major advance in the understanding of the molecular mechanisms behind aging while providing …
Adults 
12/24/12 
★★★ 
Research Sheds New Light on Mechanisms of T-ALL, a Form of Leukemia That Primarily Affects Children
By VIB (the Flanders Institute for Biotechnology)
Acute lymphatic leukemia (ALL) is the most common cancer in children under the age of 14 years. With optimum treatment, approximately 75 % of children are currently cured, but …
Ctcs 
3/26/12 
Some Scum! Microbe in Pond Scum Enlisted in New Cancer Test
By American Chemical Society
Scientists are enlisting the living, self-propelled microbes found in pond scum — the pea-green surface slicks that form on ponds — in the development of a long-awaited new test …
Cells 
12/17/13 
Moffitt Researchers Discover Mechanism Controlling the Development of Myelodysplastic
By H. Lee Moffitt Cancer Center & Research Institute
Researchers at the Moffitt Cancer Center have discovered a control mechanism that can trigger the development of myelodysplastic syndromes (MDS), a group of blood cancers. This finding may lead …
Stage 
3/23/13 
Detecting Circulating Tumor Cells
By American Institute of Physics
About 1 in 4 deaths in the United States are due to cancer, but primary tumors are rarely fatal. Instead, it's when tumors metastasize that cancer becomes so deadly. …
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