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SDSC Resources, Expertise Used in Genomic Analysis of 115 Year-old Woman

Published: April 30, 2014.
By University of California - San Diego
http://www.ucsd.edu

A team of researchers investigating the genome of a healthy supercentenarian since 2011 has found many somatic mutations – permanent changes in cells other than reproductive ones – that arose during the woman's lifetime. Led by Erik Sistermans and Henne Holstege from the VU University Medical Center in Amsterdam, the team recently published its findings in the journal Genome Research as reported by GenomeWeb.


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medicine
Signaling Molecule Crucial to Stem Cell Reprogramming
While investigating a rare genetic disorder, researchers at the University of California, San Diego School of Medicine have discovered that a ubiquitous signaling molecule is crucial to cellular reprogramming, a finding with significant implications for stem cell-based regenerative medicine, wound repair therapies and potential cancer treatments. The findings are published in the Nov. 20 online issue of Cell Reports.
biology
Of Mice, Not Men
For more than a century, the laboratory mouse (Mus musculus) has stood in for humans in experiments ranging from deciphering disease and brain function to explaining social behaviors and the nature of obesity. The small rodent has proven to be an indispensable biological tool, the basis for decades of profound scientific discovery and medical progress.
medicine
Chemical Disguise Transforms RNAi Drug Delivery
Small pieces of synthetic RNA trigger a RNA interference (RNAi) response that holds great therapeutic potential to treat a number of diseases, especially cancer and pandemic viruses. The problem is delivery -- it is extremely difficult to get RNAi drugs inside the cells in which they are needed. To overcome this hurdle, researchers at University of California, San Diego School of Medicine have developed a way to chemically disguise RNAi drugs so that they are able to enter cells. Once inside, cellular machinery…
medicine
Multiple Models Reveal New Genetic Links in Autism
With the help of mouse models, induced pluripotent stem cells (iPSCs) and the "tooth fairy," researchers at the University of California, San Diego School of Medicine have implicated a new gene in idiopathic or non-syndromic autism. The gene is associated with Rett syndrome, a syndromic form of autism, suggesting that different types of autism spectrum disorder (ASD) may share similar molecular pathways.
technology
Wireless Devices Used by Casual Pilots Vulnerable to Hacking, Computer Scientists Find
A new class of apps and wireless devices used by private pilots during flights for everything from GPS information to data about nearby aircraft is vulnerable to a wide range of security attacks, which in some scenarios could lead to catastrophic outcomes, according to computer scientists at the University of California, San Diego and Johns Hopkins University. They presented their findings Nov. 5 at the 21st ACM Conference on Computer and Communications Security in Scottsdale, Ariz. ` Researchers examined three combinations of devices…
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