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SDSC Resources, Expertise Used in Genomic Analysis of 115 Year-old Woman

Published: April 30, 2014.
Released by University of California - San Diego  

A team of researchers investigating the genome of a healthy supercentenarian since 2011 has found many somatic mutations – permanent changes in cells other than reproductive ones – that arose during the woman's lifetime. Led by Erik Sistermans and Henne Holstege from the VU University Medical Center in Amsterdam, the team recently published its findings in the journal Genome Research as reported by GenomeWeb.

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More news from University of California - San Diego

Alcohol Also Damages the Liver by Allowing Bacteria to Infiltrate
Alcohol itself can directly damage liver cells. Now researchers at University of California, San Diego School of Medicine report evidence that alcohol is also harmful to the liver for a second reason -- it allows gut bacteria to migrate to the liver, promoting alcohol-induced liver disease. The study, conducted in mice and in laboratory samples, is published February 10 in Cell Host & Microbe.

Engineers 3-D-print a New Lifelike Liver Tissue for Drug Screening
A team led by engineers at the University of California, San Diego has 3D-printed a tissue that closely mimics the human liver's sophisticated structure and function. The new model could be used for patient-specific drug screening and disease modeling. The work was published the week of Feb. 8 in the online early edition of Proceedings of the National Academy of Sciences.

New Algorithm Improves Speed And Accuracy of Pedestrian Detection
What if computers could recognize objects as well as the human brain could? Electrical engineers at the University of California, San Diego have taken an important step toward that goal by developing a pedestrian detection system that performs in near real-time (2-4 frames per second) and with higher accuracy (close to half the error) compared to existing systems. The technology, which incorporates deep learning models, could be used in "smart" vehicles, robotics and image and video search systems.

Scripps-led Team Discovers 4 New Deep-sea Worm Species
A pink flatworm-like animal known by a single species found in waters off Sweden has puzzled biologists for nearly six decades. New discoveries half a world away by a team of scientists from Scripps Institution of Oceanography at UC San Diego, the Western Australian Museum, and the Monterey Bay Aquarium Research Institute (MBARI) have helped properly identify these elusive creatures through genetic analysis.

Cholesterol Levels Improve with Weight Loss And Healthy Fat-rich Diet
A University of California, San Diego School of Medicine study finds that weight loss programs that provide healthy fats, such as olive oil in the Mediterranean diet, or a low-fat, high-carbohydrate diet have similar impacts on pound-shedding. More specifically, the researchers report that a meal plan rich in walnuts, which are high in polyunsaturated fats, has a significant impact on lipid levels for women, especially those who are insulin-resistant.

Study Finds Toxic Pollutants in Fish Across the World's Oceans
A new global analysis of seafood found that fish populations throughout the world's oceans are contaminated with industrial and agricultural pollutants, collectively known as persistent organic pollutants (POPs). The study from researchers at Scripps Institution of Oceanography at UC San Diego also uncovered some good news?concentrations of these pollutants have been consistently dropping over the last 30 years.

E-cigarette Vapor Boosts Superbugs And Dampens Immune System
Researchers at the University of California, San Diego School of Medicine and Veterans Affairs San Diego Healthcare System report data suggesting that e-cigarettes are toxic to human airway cells, suppress immune defenses and alter inflammation, while at the same time boosting bacterial virulence. The mouse study is published January 25 by the Journal of Molecular Medicine.

Biologists Develop Method for Antibiotic Susceptibility Testing
A team of biologists and biomedical researchers at UC San Diego has developed a new method to determine if bacteria are susceptible to antibiotics within a few hours, an advance that could slow the appearance of drug resistance and allow doctors to more rapidly identify the appropriate treatment for patients with life threatening bacterial infections.

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