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SDSC Resources, Expertise Used in Genomic Analysis of 115 Year-old Woman

Published: April 30, 2014.
Released by University of California - San Diego  

A team of researchers investigating the genome of a healthy supercentenarian since 2011 has found many somatic mutations – permanent changes in cells other than reproductive ones – that arose during the woman's lifetime. Led by Erik Sistermans and Henne Holstege from the VU University Medical Center in Amsterdam, the team recently published its findings in the journal Genome Research as reported by GenomeWeb.

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More news from University of California - San Diego

Current Screening Methods Miss Worrisome Number of Persons with Mild Cognitive Impairment
Mild cognitive impairment (MCI) is a slight but noticeable and measurable decline in cognitive abilities, such as remembering names or a list of items. While changes may not be severe enough to disrupt daily life, a clinical diagnosis of MCI indicates an increased risk of eventually developing Alzheimer's disease or another type of dementia.

Engineers Take First Step Toward Flexible, Wearable, Tricoder-like Device
Engineers at the University of California San Diego have developed the first flexible wearable device capable of monitoring both biochemical and electric signals in the human body. The Chem-Phys patch records electrocardiogram (EKG) heart signals and tracks levels of lactate, a biochemical that is a marker of physical effort, in real time. The device can be worn on the chest and communicates wirelessly with a smartphone, smart watch or laptop. It could have a wide range of applications, from athletes monitoring their workouts…

High Levels of Protein P62 Predict Liver Cancer Recurrence
Researchers at University of California San Diego School of Medicine and Sanford Burnham Prebys Medical Discovery Institute have discovered that high levels of the protein p62 in human liver samples are strongly associated with cancer recurrence and reduced patient survival. In mice, they also found that p62 is required for liver cancer to form.

Blocking Known Cancer Driver Unexpectedly Reveals a New Tumor-promoting Pathway
While investigating a potential therapeutic target for the ERK1 and 2 pathway, a widely expressed signaling molecule known to drive cancer growth in one third of patients with colorectal cancer, University of California San Diego School of Medicine researchers found that an alternative pathway immediately emerges when ERK1/2 is halted, thus allowing tumor cell proliferation to continue.

First Peek into the Brain of a Freely Walking Fruit Fly
Researchers at the Kavli Institute for Brain and Mind at the University of California San Diego have developed a technique for imaging brain activity in a freely walking fruit fly. Working with one of the most common model organisms in science, Drosophila melanogaster, the team shows for the first time what goes on in the brain of the fly during courtship -- when it's unrestrained. Dubbed "Flyception" by the researchers, the novel imaging system is described in Nature Methods.

Immunization with Bacteria Promotes Stress Resilience, Coping Behaviors in Mice
Injections of the soil bacterium Mycobacterium vaccae promote stress resilience and improve coping behaviors in mice, according to a new study led by researchers at University of California San Diego School of Medicine and University of Colorado Boulder. The researchers also found that M. vaccae prevented stress-induced colitis, a typical symptom of inflammatory bowel disease, suggesting that immunization with the bacteria may have wide-ranging health benefits.

Diabetes Drug Found No Better Than Placebo at Treating NAFLD
A diabetes medication described in some studies as an effective treatment for nonalcoholic fatty liver disease (NAFLD) works no better than a placebo, report researchers at University of California San Diego School of Medicine, after conducting the first randomized, double-blind, controlled clinical trial of sitagliptin, an oral antihyperglycemic marketed by Merck & Co. under the name Januvia.

Genetic Variants May Put Some Soldiers at Higher Risk of PTSD
In a massive analysis of DNA samples from more than 13,000 U.S. soldiers, scientists have identified two statistically significant genetic variants that may be associated with an increased risk of post-traumatic stress disorder (PTSD), an often serious mental illness linked to earlier exposure to a traumatic event, such as combat and an act of violence.

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