A team of researchers investigating the genome of a healthy supercentenarian since 2011 has found many somatic mutations – permanent changes in cells other than reproductive ones – that arose during the woman's lifetime. Led by Erik Sistermans and Henne Holstege from the VU University Medical Center in Amsterdam, the team recently published its findings in the journal Genome Research as reported by GenomeWeb.
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Signaling Molecule Crucial to Stem Cell Reprogramming
While investigating a rare genetic disorder, researchers at the University of California, San Diego School of Medicine have discovered that a ubiquitous signaling molecule is crucial to cellular reprogramming, a finding with significant implications for stem cell-based regenerative medicine, wound repair therapies and potential cancer treatments. The findings are published in the Nov. 20 online issue of Cell Reports.
Of Mice, Not Men
For more than a century, the laboratory mouse (Mus musculus) has stood in for humans in experiments ranging from deciphering disease and brain function to explaining social behaviors and the nature of obesity. The small rodent has proven to be an indispensable biological tool, the basis for decades of profound scientific discovery and medical progress.
Chemical Disguise Transforms RNAi Drug Delivery
Small pieces of synthetic RNA trigger a RNA interference (RNAi) response that holds great therapeutic potential to treat a number of diseases, especially cancer and pandemic viruses. The problem is delivery -- it is extremely difficult to get RNAi drugs inside the cells in which they are needed. To overcome this hurdle, researchers at University of California, San Diego School of Medicine have developed a way to chemically disguise RNAi drugs so that they are able to enter cells. Once inside, cellular machinery
Multiple Models Reveal New Genetic Links in Autism
With the help of mouse models, induced pluripotent stem cells (iPSCs) and the "tooth fairy," researchers at the University of California, San Diego School of Medicine have implicated a new gene in idiopathic or non-syndromic autism. The gene is associated with Rett syndrome, a syndromic form of autism, suggesting that different types of autism spectrum disorder (ASD) may share similar molecular pathways.
Wireless Devices Used by Casual Pilots Vulnerable to Hacking, Computer Scientists Find
A new class of apps and wireless devices used by private pilots during flights for everything from GPS information to data about nearby aircraft is vulnerable to a wide range of security attacks, which in some scenarios could lead to catastrophic outcomes, according to computer scientists at the University of California, San Diego and Johns Hopkins University. They presented their findings Nov. 5 at the 21st ACM Conference on Computer and Communications Security in Scottsdale, Ariz. ` Researchers examined three combinations of devices
|NIH Funds Massive Genome Studies That Identify Genetics Behind White Blood Cell Counts|
By National Heart, Lung and Blood Institute
WHAT: A trio of large-scale genome-wide association studies, or GWAS, have identified more than 15 gene variants responsible for the diversity of white blood cell counts among whites, African-Americans,
Counting White Blood Cells at Home
By California Institute of Technology
|New Research Explains How Estrogen Could Help Protect Women from Cardiovascular Disease|
By Queen Mary, University of London
The sex hormone oestrogen could help protect women from cardiovascular disease by keeping the body's immune system in check, new research from Queen Mary, University of London has revealed.
|Hide And Seek Signals|
By Weizmann Institute of Science
The white blood cells that fight disease and help our bodies heal are directed to sites of infection or injury by 'exit signs' – chemical signals that tell them
|New Stanford Immune-system Sensor May Speed Up, Slash Cost of Detecting Disease|
By Stanford University Medical Center
An inexpensive new medical sensor has the potential to simplify the diagnosis of diseases ranging from life-threatening immune deficiencies to the common cold, according to its inventors at the
|New Potential Target for Rheumatoid Arthritis|
By Newcastle University
Newcastle University scientists, in work funded by Arthritis Research UK, have discovered a new way of potentially treating rheumatoid arthritis. This works by preventing damaging white blood cells cells
|Cholesterol-lowering Statins Boost Bacteria-killing Cells|
By University of California - San Diego
Widely prescribed for their cholesterol-lowering properties, recent clinical research indicates that statins can produce a second, significant health benefit: lowering the risk of severe bacterial infections such as pneumonia
|Research Identifies the Beginnings of COPD|
By University of California - Davis Health System
The third most deadly disease in the U.S., chronic obstructive pulmonary disease (COPD), appears to be partly driven by the action of immune cells circulating in the blood entering
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