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Damage Control: Recovering from Radiation And Chemotherapy

Published: May 1, 2014.
By University of California - San Diego
http://www.ucsd.edu

Researchers at the University of California, San Diego School of Medicine report that a protein called beta-catenin plays a critical, and previously unappreciated, role in promoting recovery of stricken hematopoietic stem cells after radiation exposure.


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More news from University of California - San Diego


biology
New Genetic 'Operating System' Facilitated Evolution of 'Bilateral' Animals
The evolution of worms, insects, vertebrates and other "bilateral" animals—those with distinct left and right sides—from less complex creatures like jellyfish and sea anemones with "radial" symmetry may have been facilitated by the emergence of a completely new "operating system" for controlling genetic instructions in the cell.
technology
First Comprehensive Meshfree Numerical Simulation of Skeletal Muscle Tissue Achieved
Engineers at the University of California, San Diego, have completed the first comprehensive numerical simulation of skeletal muscle tissue using a method that uses the pixels in an image as data points for the computer simulation—a method known as mesh-free simulation.
medicine
A 'Frenemy' in Parkinson's Disease Takes to Crowdsourcing
The protein alpha-synuclein is a well-known player in Parkinson's disease and other related neurological conditions, such as dementia with Lewy bodies. Its normal functions, however, have long remained unknown. An enticing mystery, say researchers, who contend that understanding the normal is critical in resolving the abnormal.
nature
Disease Without Borders
In a paper published this week online in Global Society, researchers with University of California, San Diego School of Medicine and the Urban Studies and Planning Program, also at UC San Diego, present a bioregional guide that merges place-based (territorial) city planning and ecosystem management along the United States-Mexico border as way to improve human and environmental health.
biology
Program Predicts Placement of Chemical Tags That Control Gene Activity
Biochemists working at the University of California, San Diego, have developed a program that predicts the placement of chemical marks that control the activity of genes based on sequences of DNA. They describe their analysis and report results from its application to human embryonic cells in a paper published in Nature Methods online September 21.
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Cells 
9/15/11 
Stowers Scientists Successfully Expand Bone Marrow-derived Stem Cells in Culture
By Stowers Institute for Medical Research
KANSAS CITY, MO -- All stem cells—regardless of their source—share the remarkable capability to replenish themselves by undergoing self-renewal. Yet, so far, efforts to grow and expand scarce hematopoietic …
Blood 
7/1/13 
UCLA Stem Cell Gene Therapy for Sickle Cell Disease Advances Toward Clinical Trials
By University of California - Los Angeles
Researchers at UCLA's Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have successfully established the foundation for using hematopoietic (blood-producing) stem cells from the bone …
Hematopoietic 
10/7/13 
Study Identifies Essential Molecule in Formation of Differentiated Blood Cells
By Cincinnati Children's Hospital Medical Center
CINCINNATI – New research in the Journal of Experimental Medicine identifies a protein that controls the formation of different types of mature blood cells – a finding that could …
Stem 
7/19/12 
The Yin And Yang of Stem Cell Quiescence And Proliferation
By Stowers Institute for Medical Research
KANSAS CITY, MO—Not all adult stem cells are created equal. Some are busy regenerating worn out or damaged tissues, while their quieter brethren serve as a strategic back-up crew …
Cells 
7/17/13 
Keeping the Reserve Force Home
By Stowers Institute for Medical Research
KANSAS CITY, MO - Hematopoietic stem cells—bone marrow-derived adult stem cells that give rise to the wide variety of specialized blood cells—come in two flavors: the reserve force sits …
Animals 
9/29/14 
Researchers Show Irradiation Plus Transplantation Effective for Treating HIV/AIDS
By Emory Health Sciences
Yerkes National Primate Research Center researchers are the first to show that an irradiation plus transplantation combination approach in nonhuman primates can be used to treat or even possibly …
Cells 
9/25/14 
Stem Cell Transplant Does Not Cure SHIV/AIDS After Irradiation of Infected Rhesus Macaques
By PLOS
A study published on September 25th in PLOS Pathogens reports a new primate model to test treatments that might cure HIV/AIDS and suggests answers to questions raised by the …
Cells 
11/18/10 
Gene Therapy for Metastatic Melanoma in Mice Produces Complete Remission
By Indiana University School of Medicine
INDIANAPOLIS – A potent anti-tumor gene introduced into mice with metastatic melanoma has resulted in permanent immune reconfiguration and produced a complete remission of their cancer, according to an …
Sequences 
1/31/13 
1 of the Key Circuits in Regulating Genes Involved in Producing Blood Stem Cells Is Deciphered
By IMIM (Hospital del Mar Medical Research Institute)
Researchers from the group on stem cells and cancer at IMIM (Hospital del Mar Medical Research Institute) have deciphered one of the gene regulation circuits which would make it …
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