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Damage Control: Recovering from Radiation And Chemotherapy

Published: May 1, 2014.
Released by University of California - San Diego  

Researchers at the University of California, San Diego School of Medicine report that a protein called beta-catenin plays a critical, and previously unappreciated, role in promoting recovery of stricken hematopoietic stem cells after radiation exposure.


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medicine
Researchers Find Link Between Inflammation, Tissue Regeneration And Wound Repair Response
Almost all injuries, even minor skin scratches, trigger an inflammatory response, which provides protection against invading microbes but also turns on regenerative signals needed for healing and injury repair - a process that is generally understood but remains mysterious in its particulars.

medicine
Culture Clash: How Stem Cells Are Grown Affects Their Genetic Stability
The therapeutic promise of human stem cells is indisputably huge, but the process of translating their potential into effective, real-world treatments involves deciphering and resolving a host of daunting complexities.

medicine
Small Loop in Human Prion Protein Prevents Chronic Wasting Disease
Chronic wasting disease (CWD) -- an infectious disease caused by prions -- affects North American elk and deer, but has not been observed in humans. Using a mouse model that expresses an altered form of the normal human prion protein, researchers at University of California, San Diego School of Medicine have determined why the human proteins aren't corrupted when exposed to the elk prions. Their study, published Feb. 23 in the Journal of Clinical Investigation, identifies a small loop in the human prion…

medicine
Molecular Link Between Obesity And Type 2 Diabetes Reveals Potential Therapy
Obesity causes inflammation, which can in turn lead to type 2 diabetes. What isn't well established is how inflammation causes diabetes -- or what we can do to stop it. Researchers at University of California, San Diego School of Medicine have discovered that the inflammatory molecule LTB4 promotes insulin resistance, a first step in developing type 2 diabetes. What's more, the team found that genetically removing the cell receptor that responds to LTB4, or blocking it with a drug, improves insulin sensitivity in…

biology
Medtech Meets Cleantech: Malaria Vaccine Candidate Produced from Algae
Researchers at University of California, San Diego School of Medicine used algae as a mini-factory to produce a malaria parasite protein. The algae-produced protein, paired with an immune-boosting cocktail suitable for use in humans, generated antibodies in mice that nearly eliminated mosquito infection by the malaria parasite. The method, published Feb. 17 by Infection and Immunity, is the newest attempt to develop a vaccine that prevents transmission of the malaria parasite from host to mosquito.

medicine
Tau-associated MAPT Gene Increases Risk for Alzheimer's Disease
An international team of scientists, led by researchers at the University of California, San Diego School of Medicine, has identified the microtubule-associated protein tau (MAPT) gene as increasing the risk for developing Alzheimer's disease (AD). The MAPT gene encodes the tau protein, which is involved with a number of neurodegenerative disorders, including Parkinson's disease (PD) and AD. These findings provide novel insight into Alzheimer's neurodegeneration, possibly opening the door for improved clinical diagnosis and treatment. …

biology
New Species, the 'Ruby Seadragon,' Discovered by Scripps Researchers
While researching the two known species of seadragons as part of an effort to understand and protect the exotic and delicate fish, scientists at Scripps Institution of Oceanography at UC San Diego made a startling discovery: A third species of seadragon.

biology
New Insights into 3-D Genome Organization And Genetic Variability
While genomics is the study of all of the genes in a cell or organism, epigenomics is the study of all the genomic add-ons and changes that influence gene expression but aren't encoded in the DNA sequence. A variety of new epigenomic information is now available in a collection of studies published Feb. 19 in Nature by the National Institutes of Health (NIH) Roadmap Epigenomics Program. This information provides a valuable baseline for future studies of the epigenome's role in human development and…

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