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Damage Control: Recovering from Radiation And Chemotherapy

Published: May 1, 2014.
Released by University of California - San Diego  

Researchers at the University of California, San Diego School of Medicine report that a protein called beta-catenin plays a critical, and previously unappreciated, role in promoting recovery of stricken hematopoietic stem cells after radiation exposure.


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medicine
Programming Probiotics for Early Detection of Liver Cancer Metastases
Scientists at the University of California, San Diego and the Massachusetts Institute of Technology (MIT) have described a new method for detecting liver cancer metastases in mice. The approach uses over-the-counter probiotics genetically programmed to produce signals easily detectable in urine when liver cancer metastases are present. The results of the new study, published in the May 27 issue of Science Translational Medicine, indicate that genetically-programmed probiotics may be useful for detecting liver cancer metastases early-on in the progression of the disease. …

medicine
Ovarian Cancer-specific Markers Set the Stage for Early Diagnosis, Personalized Treatments
Ovarian cancer is notoriously difficult to diagnose and treat, making it an especially fatal disease. Researchers at University of California, San Diego School of Medicine and Moores Cancer Center have now identified six mRNA isoforms (bits of genetic material) produced by ovarian cancer cells but not normal cells, opening up the possibility that they could be used to diagnose early-stage ovarian cancer. What's more, several of the mRNA isoforms code for unique proteins that could be targeted with new therapeutics. The study is…

medicine
Human Stem Cell Model Reveals Molecular Cues Critical to Neurovascular Unit Formation
Crucial bodily functions we depend on but don't consciously think about -- things like heart rate, blood flow, breathing and digestion -- are regulated by the neurovascular unit. The neurovascular unit is made up of blood vessels and smooth muscles under the control of autonomic neurons. Yet how the nervous and vascular systems come together during development to coordinate these functions is not well understood. Using human embryonic stem cells, researchers at University of California, San Diego School of Medicine and Moores Cancer…

medicine
Youth Dance Classes Score Low in Physical Activity
For parents who send their kids to dance classes to get some exercise, a new study from researchers at University of California, San Diego School of Medicine suggests most youth dance classes provide only limited amounts of physical activity.

biology
Gel Filled with Nanosponges Cleans Up MRSA Infections
San Diego, Calif., May 13, 2015 -- Nanoengineers at the University of California, San Diego developed a gel filled with toxin-absorbing nanosponges that could lead to an effective treatment for skin and wound infections caused by MRSA (methicillin-resistant Staphylococcus aureus), an antibiotic-resistant bacteria. This "nanosponge-hydrogel" minimized the growth of skin lesions on mice infected with MRSA - without the use of antibiotics. The researchers recently published their findings online in Advanced Materials. …

biology
New Nanomaterials Inspired by Bird Feathers Play with Light to Create Color
Inspired by the way iridescent bird feathers play with light, scientists have created thin films of material in a wide range of pure colors -- from red to green -- with hues determined by physical structure rather than pigments.

medicine
New Combination Treatment Strategy to 'Checkmate' Glioblastoma
Therapies that specifically target mutations in a person's cancer have been much-heralded in recent years, yet cancer cells often find a way around them. To address this, researchers at University of California, San Diego School of Medicine and Moores Cancer Center identified a promising combinatorial approach to treating glioblastomas, the most common form of primary brain cancer.

medicine
Post-traumatic Stress Disorder Linked to Accelerated Aging
In recent years, public health concerns about post-traumatic stress disorder (PTSD) have risen significantly, driven in part by affected military veterans returning from conflicts in the Middle East and elsewhere. PTSD is associated with number of psychological maladies, among them chronic depression, anger, insomnia, eating disorders and substance abuse.

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