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Damage Control: Recovering from Radiation And Chemotherapy

Published: May 1, 2014.
By University of California - San Diego
http://www.ucsd.edu

Researchers at the University of California, San Diego School of Medicine report that a protein called beta-catenin plays a critical, and previously unappreciated, role in promoting recovery of stricken hematopoietic stem cells after radiation exposure.


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More news from University of California - San Diego


medicine
Signaling Molecule Crucial to Stem Cell Reprogramming
While investigating a rare genetic disorder, researchers at the University of California, San Diego School of Medicine have discovered that a ubiquitous signaling molecule is crucial to cellular reprogramming, a finding with significant implications for stem cell-based regenerative medicine, wound repair therapies and potential cancer treatments. The findings are published in the Nov. 20 online issue of Cell Reports.
biology
Of Mice, Not Men
For more than a century, the laboratory mouse (Mus musculus) has stood in for humans in experiments ranging from deciphering disease and brain function to explaining social behaviors and the nature of obesity. The small rodent has proven to be an indispensable biological tool, the basis for decades of profound scientific discovery and medical progress.
medicine
Chemical Disguise Transforms RNAi Drug Delivery
Small pieces of synthetic RNA trigger a RNA interference (RNAi) response that holds great therapeutic potential to treat a number of diseases, especially cancer and pandemic viruses. The problem is delivery -- it is extremely difficult to get RNAi drugs inside the cells in which they are needed. To overcome this hurdle, researchers at University of California, San Diego School of Medicine have developed a way to chemically disguise RNAi drugs so that they are able to enter cells. Once inside, cellular machinery…
medicine
Multiple Models Reveal New Genetic Links in Autism
With the help of mouse models, induced pluripotent stem cells (iPSCs) and the "tooth fairy," researchers at the University of California, San Diego School of Medicine have implicated a new gene in idiopathic or non-syndromic autism. The gene is associated with Rett syndrome, a syndromic form of autism, suggesting that different types of autism spectrum disorder (ASD) may share similar molecular pathways.
technology
Wireless Devices Used by Casual Pilots Vulnerable to Hacking, Computer Scientists Find
A new class of apps and wireless devices used by private pilots during flights for everything from GPS information to data about nearby aircraft is vulnerable to a wide range of security attacks, which in some scenarios could lead to catastrophic outcomes, according to computer scientists at the University of California, San Diego and Johns Hopkins University. They presented their findings Nov. 5 at the 21st ACM Conference on Computer and Communications Security in Scottsdale, Ariz. ` Researchers examined three combinations of devices…
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Bone 
7/29/13 
Could Sleeping Stem Cells Hold Key to Treatment of Aggressive Blood Cancer?
By Queen Mary, University of London
Scientists studying an aggressive form of leukaemia have discovered that rather than displacing healthy stem cells in the bone marrow as previously believed, the cancer is putting them to …
Marrow 
1/31/13 
Diabetes Distresses Bone Marrow Stem Cells by Damaging Their Microenvironment
By University of Bristol
New research has shown the presence of a disease affecting small blood vessels, known as microangiopathy, in the bone marrow of diabetic patients. While it is well known that …
Cells 
2/3/13 
Growth Factor Aids Stem Cell Regeneration After Radiation Damage
By Duke University Medical Center
DURHAM, N.C. – Epidermal growth factor has been found to speed the recovery of blood-making stem cells after exposure to radiation, according to Duke Medicine researchers. The finding could …
Cells 
3/1/11 
How Long Do Stem Cells Live?
By Sanford-Burnham Medical Research Institute
LA JOLLA, Calif., March 1, 2011 – When patients receive a bone marrow transplant, they are getting a new population of hematopoietic stem cells. Fresh stem cells are needed …
Transplant 
10/19/12 
Moffitt Researcher Says No Survival Advantage with Peripheral Blood Stem Cells Versus Bone Marrow
By H. Lee Moffitt Cancer Center & Research Institute
Claudio Anasetti, M.D., chair of the Department of Blood & Marrow Transplant at Moffitt Cancer Center, and colleagues from 47 research sites in the Blood and Marrow Transplant Clinical …
Infection 
6/9/10 
Gamma Interferon a Wake-up Call for Stem Cell Response to Infection
By Baylor College of Medicine
HOUSTON -- (June 10, 2010) – Most of the time, the body's blood-forming (hematopoietic) stem cells remain dormant, with just a few producing blood cells and maintaining a balance …
Cells 
6/28/13 
Type 2 Diabetes Patients Transplanted with Own Bone Marrow Stem Cells Reduces Insulin Use
By Cell Transplantation Center of Excellence for Aging and Brain Repair
Putnam Valley, NY. (June 28 2013) –A study carried out in India examining the safety and efficacy of self-donated (autologous), transplanted bone marrow stem cells in patients with type …
Cells 
10/3/12 
Cedars-Sinai Study Sheds Light on Bone Marrow Stem Cell Therapy for Pancreatic Recovery
By Cedars-Sinai Medical Center
LOS ANGELES (Oct. 2, 2012) – Researchers at Cedars-Sinai's Maxine Dunitz Neurosurgical Institute have found that a blood vessel-building gene boosts the ability of human bone marrow stem cells …
Cells 
10/22/12 
★★★ 
Stem Cell Bodyguards
By Weizmann Institute of Science
Hiding deep inside the bone marrow are special cells. They wait patiently for the hour of need, at which point these blood forming stem cells can proliferate and differentiate …
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