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Damage Control: Recovering from Radiation And Chemotherapy

Published: May 1, 2014.
Released by University of California - San Diego  

Researchers at the University of California, San Diego School of Medicine report that a protein called beta-catenin plays a critical, and previously unappreciated, role in promoting recovery of stricken hematopoietic stem cells after radiation exposure.


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biology
3-D Human Skin Maps Aid Study of Relationships Between Molecules, Microbes And Environment
Researchers at the University of California, San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences used information collected from hundreds of skin swabs to produce three-dimensional maps of molecular and microbial variations across the body. These maps provide a baseline for future studies of the interplay between the molecules that make up our skin, the microbes that live on us, our personal hygiene routines and other environmental factors. The study, published March 30 by Proceedings of the National Academy of Sciences, may help…

technology
Engineers Develop New Methods to Speed Up Simulations in Computational Grand Challenge
Engineers at the University of California, San Diego, have developed a new family of methods to significantly increase the speed of time-resolved numerical simulations in computational grand challenge problems. Such problems often arise from the high-resolution approximation of the partial differential equations governing complex flows of fluids or plasmas. The breakthrough could be applied to simulations that include millions or billions of variables, including turbulence simulations.

nature
Antarctic Ice Shelves Rapidly Thinning
A new study led by Scripps Institution of Oceanography at UC San Diego researchers has revealed that the thickness of Antarctica's floating ice shelves has recently decreased by as much as 18 percent in certain areas over nearly two decades, providing new insights on how the Antarctic ice sheet is responding to climate change.

medicine
Control Switch That Modulates Cell Stress Response May Be Key to Multiple Diseases
Researchers at the University of California, San Diego School of Medicine have discovered a control switch for the unfolded protein response (UPR), a cellular stress relief mechanism drawing major scientific interest because of its role in cancer, diabetes, inflammatory disorders and several neural degenerative disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), otherwise known as Lou Gehrig's disease.

medicine
SDSC/UCSD Study Uncovers Mechanisms of Cancer-causing Mutations
Researchers at the San Diego Supercomputer Center (SDSC) and the Moores Cancer Center at the University of California, San Diego, have described for the first time the molecular mechanism of cancer development caused by well-known "resistance" mutations in the gene called epidermal growth factor receptor (EGFR). While these mutations were known for quite a long time, the question as to why they cause cancer or make some drugs ineffective was still not answered.

biology
Researchers Rethink How Our Feathered Friends Evolved
A recently published global genome study that used the data-intensive Gordon supercomputer at the San Diego Supercomputer at the University of California, San Diego, has researchers rethinking how avian lineages diverged after the extinction of the dinosaurs.

medicine
Boosting a Natural Protection Against Alzheimer's Disease
Researchers at the University of California, San Diego School of Medicine have identified a gene variant that may be used to predict people most likely to respond to an investigational therapy under development for Alzheimer's disease (AD). The study, published March 12 in Cell Stem Cell, is based on experiments with cultured neurons derived from adult stem cells.

medicine
Gene Networks for Innate Immunity Linked to PTSD Risk
Researchers at the Veterans Affairs San Diego Healthcare System and University of California, San Diego School of Medicine, with colleagues in New York and the United Kingdom, have identified genetic markers, derived from blood samples that are linked to post-traumatic stress disorder (PTSD). The markers are associated with gene networks that regulate innate immune function and interferon signaling.

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